Sphere-forming stem-like cell populations with drug resistance in human sarcoma cell lines
…, T Tsujiuchi, A Kido, K Yoshitani… - International …, 2009 - spandidos-publications.com
The presence of cancer stem cells in both solid and hematopoietic malignancies, has been
recently linked to their pathogenesis. Sarcomas are rare, and diversely characterized by …
recently linked to their pathogenesis. Sarcomas are rare, and diversely characterized by …
Expression of the p16INK4a gene and methylation pattern of CpG sites in the promoter region in rat tumor cell lines
…, T Tsujiuchi, T Mori, K Yoshitani… - … in cooperation with …, 2004 - Wiley Online Library
Loss of p16 INK4a protein expression has frequently been related to DNA methylation in
association with gene silencing. Although the methylation status of exon1α for p16 INK4a …
association with gene silencing. Although the methylation status of exon1α for p16 INK4a …
Growth inhibition and induction of apoptosis by flavopiridol in rat lung adenocarcinoma, osteosarcoma and malignant fibrous histiocytoma cell lines
K Honoki, K Yoshitani, T Tsujiuchi… - Oncology …, 2004 - spandidos-publications.com
Flavopiridol is the potent inhibitor of cdks sharing its function with endogenous cdk inhibitors,
and causes arrest at both the G1 and G2 phases of the cell cycle resulting in apoptosis in …
and causes arrest at both the G1 and G2 phases of the cell cycle resulting in apoptosis in …
Growth inhibition of rat osteosarcoma and malignant fibrous histiocytoma cells by tyrosine kinase inhibitor STI571.
STI571 is a 2-phenylaminopyrimide derivative that was designed as an Abl tyrosine kinase
inhibitor, but it is also effective against platelet-derived growth factor receptor (PDGFR) and c-…
inhibitor, but it is also effective against platelet-derived growth factor receptor (PDGFR) and c-…
[HTML][HTML] Effect of mesenchymal stem cells on hypoxia‑induced desensitization of β2-adrenergic receptors in rat osteosarcoma cells
A Kido, K Yoshitani, T Shimizu… - Oncology …, 2012 - spandidos-publications.com
The β2-adrenergic receptor (β2AR) mediates the effects of chronic stress in several neoplasms,
however, β2AR signaling is impaired by hypoxia in various tissues. While hypoxia is a …
however, β2AR signaling is impaired by hypoxia in various tissues. While hypoxia is a …
Reduced expression of INK4a/ARF genes in stem-like sphere cells from rat sarcomas
The presence of cancer stem cells, in both hematopoietic and solid malignancies, has been
recently linked to their pathogenesis. We aimed to identify the characteristics and stem-like …
recently linked to their pathogenesis. We aimed to identify the characteristics and stem-like …
[PDF][PDF] Pelvic metastasis of breast synovial sarcoma
Synovial sarcomas, which account for approximately 10% of all malignant soft tissue tumors,
arise most commonly in the paraarticular tissues in adolescents and young adults. 1.2 It has …
arise most commonly in the paraarticular tissues in adolescents and young adults. 1.2 It has …
Low concentrations of alendronate increase the local invasive potential of osteoblastic sarcoma cell lines via connexin 43 activation
Bisphosphonates (BPs) are agents used for treating disorders of excessive bone resorption.
In addition, due to their cell-killing activity, BPs were potent candidates for adjuvant cancer …
In addition, due to their cell-killing activity, BPs were potent candidates for adjuvant cancer …
Growth inhibition and induction of apoptosis by 2-methoxyestradiol in rat osteosarcoma and malignant fibrous histiocytoma cell lines
2-Methoxyestradiol (2-ME) has been found to possess antitumor activity in vivo and in vitro. It
has been suggested that 2-ME induces apoptosis resulting in G 2 /M arrest of tumor cells. In …
has been suggested that 2-ME induces apoptosis resulting in G 2 /M arrest of tumor cells. In …
Growth inhibition and induction of apoptosis by 2-methoxyestradiol and valproic acid in rat osteosarcoma and malignant fibrous histiocytoma cell lines
4682 2-methoxyestradiol (2-ME) is a physiological metabolite of the endogenous estrogens
and has been shown its highly potent anti-tumor activity that effectively induces apoptosis in …
and has been shown its highly potent anti-tumor activity that effectively induces apoptosis in …