Guidelines for gastroenterological endoscopy in patients undergoing antithrombotic treatment

K Fujimoto, M Fujishiro, M Kato, K Higuchi… - Digestive …, 2014 - Wiley Online Library
Kazuhide HiguchiKazuhide HiguchiKazuhide Higuchi (The Japan Gastroenterological
Endoscopy Society: Osaka Medical College Second Department of Internal Medicine) …

[HTML][HTML] Present status and strategy of NSAIDs-induced small bowel injury

K Higuchi, E Umegaki, T Watanabe, Y Yoda… - Journal of …, 2009 - Springer
Non-steroidal anti-inflammatory drugs (NSAIDs) are well known to cause gastroduodenal
mucosal lesions as an adverse effect. Recently, the serious problem of NSAID-induced small …

[HTML][HTML] Evidence-based clinical practice guidelines for gastroesophageal reflux disease 2015

…, S Ohara, H Kashiwagi, K Adachi, K Higuchi… - Journal of …, 2016 - Springer
As an increase in gastroesophageal reflux disease (GERD) has been reported in Japan,
and public interest in GERD has been increasing, the Japanese Society of Gastroenterology …

[HTML][HTML] Metabolic syndrome and sarcopenia

…, A Asai, S Fukunishi, S Nishiguchi, K Higuchi - Nutrients, 2021 - mdpi.com
Skeletal muscle is a major organ of insulin-induced glucose metabolism. In addition, loss of
muscle mass is closely linked to insulin resistance (IR) and metabolic syndrome (Met-S). …

Non-steroidal anti-inflammatory drug-induced small intestinal damage is Toll-like receptor 4 dependent

T Watanabe, K Higuchi, A Kobata, H Nishio… - Gut, 2008 - gut.bmj.com
Background: Enterobacteria and cytokines both play roles in the pathophysiology of NSAID-induced
enteropathy. Toll-like receptor (TLR) 4 recognises lipopolysaccharide (LPS), …

[HTML][HTML] Cancer cachexia: its mechanism and clinical significance

…, S Fukunishi, A Asai, S Nishiguchi, K Higuchi - International journal of …, 2021 - mdpi.com
The term “cachexia” is derived from the Greek words kakos (bad) and hexis (habit). Cachexia
is a malnutrition associated with chronic diseases such as cancer, chronic heart failure, …

[HTML][HTML] Evidence-based clinical practice guidelines for functional dyspepsia

…, N Manabe, A Inui, K Haruma, K Higuchi… - Journal of …, 2015 - Springer
General interest in functional gastrointestinal disorders is increasing among Japanese
doctors as well as patients. This increase can be attributed to a number of factors, including …

Small bowel injury by low-dose enteric-coated aspirin and treatment with misoprostol: a pilot study

…, K Tominaga, Y Fujiwara, N Oshitani, K Higuchi… - Clinical …, 2008 - Elsevier
BACKGROUND & AIMS: With capsule endoscopy, the ulcerogenic effect of low-dose enteric-coated
aspirin on the small bowel and the therapeutic effect of misoprostol on intestinal …

Probiotic Lactobacillus casei strain Shirota prevents indomethacin-induced small intestinal injury: involvement of lactic acid

…, T Asahara, K Nomoto, K Higuchi… - American Journal …, 2009 - journals.physiology.org
Inflammatory responses triggered by activation of the lipopolysaccharide (LPS)/Toll-like receptor
(TLR) 4 signaling pathway are a key mechanism in nonsteroidal anti-inflammatory drug-…

[HTML][HTML] Pathophysiology and mechanisms of primary sarcopenia

…, S Nishiguchi, K Higuchi - International …, 2021 - spandidos-publications.com
Aging causes skeletal muscle atrophy, and myofiber loss can be a critical component of this
process. In 1989, Rosenberg emphasized the importance of the loss of skeletal muscle …