Quercetin, a flavonoid, is an inhibitor of P-glycoprotein-mediated efflux transport, and its
oxidative metabolism is catalyzed by CYP enzymes. Thus, it is expected that the …

Orally administered tamoxifen undergoes a first-pass metabolism and substrates for multidrug
resistance (MDR) transporters efflux in the liver and intestines, which obstructs its systemic …

The aim of this study was to investigate the effect of quercetin on the bioavailability of paclitaxel
after the oral administration of paclitaxel or a prodrug to rats pretreated with quercetin. …

Piroxicam can be ionized as a zwitterion that has two pKa values (pKa 1 =1.86 and pKa 2 =5.46).
Consequently, piroxicam has a low solubility in both polar and nonpolar media, and a …

As many anticancer agents paclitaxel is a substrate for ATP-binding cassette (ABC) transporters
such as P-glycoprotein-mediated efflux, and its metabolism in humans mainly catalyzed …

The effects of epigallocatechin gallate (EGCG) on the oral bioavailability and pharmacokinetics
of tamoxifen and its metabolite, 4-hydroxytamoxifen, were investigated in rats. A single …

To increase the dissolution rate of furosemide, cogrinding or coprecipitating of furosemide
with crospovidone was carried out. The 1:2 (w/w) ground mixture of furosemide with …

The aim of this study was to investigate the effect of quercetin on the bioavailability of
diltiazem after administering diltiazem (15mg/kg) orally to rabbits either co-administered or …

The aim of this study was to investigate the effect of naringin on the bioavailability and
pharmacokinetics of paclitaxel after oral administration of paclitaxel or its prodrug coadministered …

The pharmacokinetics and bioavailability of triamcinolone acetonide were determined to
investigate buccal absorption from the mucoadhesive gels in rabbits. The enhancing effect of …