Objectives : This study investigated whether myocardial phosphodiesterase-2 (PDE2) is altered
in heart failure (HF) and determined PDE2-mediated effects on beta-adrenergic receptor …

Purpose Assessment of HER2 overexpression using immunohistochemistry (IHC) and/or in
situ hybridisation (ISH) for the detection of HER2 amplifications is standard to identify …

Purpose BRCA1/2 mutations influence the molecular characteristics and the effects of
systemic treatment of breast cancer. This study investigates the impact of germline BRCA1/2 …

Recent studies suggest that the signal molecules cAMP and cGMP have antifibrotic effects
by negatively regulating pathways associated with fibroblast to myofibroblast (MyoCF) …

The objective of this IRB approved retrospective study was to apply deep learning to identify
magnetic resonance imaging (MRI) artifacts on maximum intensity projections (MIP) of the …

Abstract Analysis of circulating cell-free DNA (ccfDNA) is a suitable tool for detecting somatic
mutations for the purpose of making decisions on treatment, monitoring treatment response, …

We used a shifted-excitation Raman difference spectroscopy method for the ex vivo
classification of resected and formalin-fixed breast tissue samples as normal (healthy) tissue, …

Purpose To intra-individually compare patient comfort of spiral breast computed tomography
(SBCT) versus digital mammography (DM). Method This prospective IRB approved study …

Background X‐ray dark‐field radiography could enhance mammography by providing more
information on imaged tissue and microcalcifications. The dark field signal is a measure of …

Simple Summary Vaginal intraepithelial neoplasia (VaIN) is a rare premalignant disease, with
an incidence ranging from 0.2 to 2 per 100,000 women per year. Although the risk factors …