Vanillin suppresses metastatic potential of human cancer cells through PI3K inhibition and decreases angiogenesis in vivo

K Lirdprapamongkol, JP Kramb… - Journal of agricultural …, 2009 - ACS Publications
Vanillin, a food flavoring agent, has been shown to suppress cancer cell migration and
metastasis in a mouse model, but its mechanism of action is unknown. In this report, we have …

Novel 3-azaindolyl-4-arylmaleimides exhibiting potent antiangiogenic efficacy, protein kinase inhibition, and antiproliferative activity

…, A Maderer, T Stauder, JP Kramb… - Journal of Medicinal …, 2012 - ACS Publications
Tumor growth and metastasis are highly associated with the overexpression of protein kinases
(PKs) regulating cell growth, apoptosis resistance, and prolonged cell survival. This study …

Juice of Eclipta prostrata inhibits cell migration in vitro and exhibits anti-angiogenic activity in vivo

K Lirdprapamongkol, JP Kramb… - in vivo, 2008 - iv.iiarjournals.org
Background: The invasion of cancer cells is critical for metastasis. The effects of Eclipta
prostrata, a Thai medicinal plant, on invasion, migration and adhesion of cancer cells were …

3, 4-Diarylmaleimides—a novel class of kinase inhibitors—effectively induce apoptosis in FLT3-ITD-dependent cells

…, MC Blum, DB Lipka, A Ballaschk, JP Kramb… - Annals of …, 2012 - Springer
FLT3 kinase has become an attractive drug target in AML with up to 30% of cases harboring
internal-tandem-duplication (ITD) mutations. For these, conferring a worse prognosis and …

Moguntinones—New selective inhibitors for the treatment of human colorectal cancer

A Maderer, S Plutizki, JP Kramb, K Göpfert… - Molecular cancer …, 2014 - AACR
3-Indolyl and 3-azaindolyl-4-aryl maleimide derivatives, called moguntinones (MOG), have
been selected for their ability to inhibit protein kinases associated with angiogenesis and …

Investigations Concerning the Correlation of COX‐1 Inhibitory and Hydroxyl Radical Scavenging Activity

…, H Ulbrich, A Mattern, JP Kramb… - … der Pharmazie: An …, 2008 - Wiley Online Library
The aim was to study the COX‐1 inhibiting efficacy in context with hydroxyl radical scavenging
properties of compounds bearing a carboxylic acid and ester function, respectively. In …

[PDF][PDF] New Selective Inhibitors for the Treatment of−− Moguntinones

A Maderer, S Plutizki, JP Kramb - academia.edu
3-Indolyl and 3-azaindolyl-4-aryl maleimide derivatives, called moguntinones (MOG), have
been selected for their ability to inhibit protein kinases associated with angiogenesis and …

Homodimers of vanillin and apocynin decrease the metastatic potential of human cancer cells by inhibiting the FAK/PI3K/Akt signaling pathway

P Jantaree, K Lirdprapamongkol… - Journal of agricultural …, 2017 - ACS Publications
The spread of cancer cells to distant organs, in a process called metastasis, is the main factor
that contributes to most death in cancer patients. Vanillin, the vanilla flavoring agent, has …

[PDF][PDF] Chemical Composition and Medicinal Significance of Eclipta Alba: A Review

S Kumar - Phytochemistry, 2019 - academia.edu
The plant Eclipta alba Hassk (Family-Asteraceae) is locally known as Bhringaraj in India. It
is used as traditional medicine for the treatment of numerous ailments such as …

[PDF][PDF] A Critical Review of Indian Medicinal Plants for Hepatocellular Carcinoma

N Bhatt, M Deshpande - interscience.org.uk
Progression of chronic liver disease to hepatocellular carcinoma is not uncommon in India.
Approximately 22,000 new cases of primary liver cancer are reported annually in the country. …