Circulating serum miRNA (miR-367-3p, miR-371a-3p, miR-372-3p and miR-373-3p) as biomarkers in patients with testicular germ cell cancer

I Syring, J Bartels, S Holdenrieder… - The Journal of …, 2015 - auajournals.org
Purpose : Classic serum tumor markers (human chorionic gonadotropin, α1-fetoprotein and
lactate dehydrogenase) have an important role in managing testicular germ cell tumor. Since …

Pan-cancer analysis of the mediator complex transcriptome identifies CDK19 and CDK8 as therapeutic targets in advanced prostate cancer

…, D Böhm, M Deng, A Queisser, C Sanders, I Syring… - Clinical Cancer …, 2017 - AACR
Purpose: The Mediator complex is a multiprotein assembly, which serves as a hub for diverse
signaling pathways to regulate gene expression. Because gene expression is frequently …

[HTML][HTML] Identification of novel long non-coding RNAs in clear cell renal cell carcinoma

JJC Blondeau, M Deng, I Syring, S Schrödter… - Clinical …, 2015 - Springer
Background Long non-coding RNAs (lncRNA) play an important role in carcinogenesis;
knowledge on lncRNA expression in renal cell carcinoma is rudimental. As a basis for biomarker …

[HTML][HTML] Identification of the dopamine transporter SLC6A3 as a biomarker for patients with renal cell carcinoma

S Schrödter, M Braun, I Syring, N Klümper, M Deng… - Molecular cancer, 2016 - Springer
Background Clear cell renal cell carcinoma (ccRCC) is among the most common human
malignancies. Methods In order to provide better understanding of the molecular biology of …

[HTML][HTML] The long non-coding RNA lnc-ZNF180-2 is a prognostic biomarker in patients with clear cell renal cell carcinoma

…, M Deng, D Schmidt, I Syring… - American journal of …, 2015 - ncbi.nlm.nih.gov
Clear cell renal cell carcinoma (ccRCC) is among the most common human malignancies.
Long non-coding RNAs (lncRNA) regulate various cellular functions and have been …

[PDF][PDF] MED12 overexpression is a frequent event in castration-resistant prostate cancer

…, A Offermann, M Braun, R Menon, I Syring… - Endocr Relat …, 2014 - scholar.archive.org
In a recent effort to unravel the molecular basis of prostate cancer (PCa), Barbieri and
colleagues using whole-exome sequencing identified a novel recurrently mutated gene, MED12, …

Influence of body mass index on clinical outcome parameters, complication rate and survival after radical cystectomy: evidence from a prospective European …

…, MW Vetterlein, M Fisch, PJ Bastian, I Syring… - Urologia …, 2018 - karger.com
Background/Aims/Objectives: To evaluate the influence of body mass index (BMI) on complications
and oncological outcomes in patients undergoing radical cystectomy (RC). Methods: …

Cell-Free SHOX2 DNA Methylation in Blood as a Molecular Staging Parameter for Risk Stratification in Renal Cell Carcinoma Patients: A Prospective Observational …

M Jung, J Ellinger, H Gevensleben, I Syring… - Clinical …, 2019 - academic.oup.com
BACKGROUND Novel targeted treatments and immunotherapies have substantially changed
therapeutic options for advanced and metastatic renal cell carcinomas (RCCs). However, …

Effect of hospital and surgeon case volume on perioperative quality of care and short-term outcomes after radical cystectomy for muscle-invasive bladder cancer …

…, P Schramek, C Seitz, D Sikic, CG Stief, I Syring… - Clinical Genitourinary …, 2017 - Elsevier
Background Case volume has been suggested to affect surgical outcomes in different arrays
of procedures. We aimed to delineate the relationship between case volume and surgical …

[HTML][HTML] Comprehensive analysis of the transcriptional profile of the Mediator complex across human cancer types

I Syring, N Klümper, A Offermann, M Braun, M Deng… - Oncotarget, 2016 - ncbi.nlm.nih.gov
The Mediator complex is a key regulator of gene transcription and several studies demonstrated
altered expressions of particular subunits in diverse human diseases, especially cancer. …