[HTML][HTML] A pilot study of the predictive potential of chemosensitivity and gene expression assays using circulating tumour cells from patients with recurrent ovarian …

…, D Sarti, M Deraco, S Kusamura, I Papasotiriou… - International Journal of …, 2020 - mdpi.com
Circulating tumour cells (CTCs) from liquid biopsies are under current investigation in several
cancers, including epithelial ovarian cancer (EOC) but face significant drawbacks in terms …

Correlation between cancer stem cells and circulating tumor cells and their value

…, P Apostolou, M Chatziioannou, I Papasotiriou - Case reports in …, 2011 - karger.com
Background: The scientific community has proven the value of circulating tumor cells (CTCs)
as a prognostic factor in the development of cancer and progress to metastases [1–4]. …

[HTML][HTML] Structural models of human ACE2 variants with SARS-CoV-2 Spike protein for structure-based drug design

…, S Barrera-Vilarmau, R Paschke, I Papasotiriou… - Scientific data, 2020 - nature.com
Emergence of coronaviruses poses a threat to global health and economy. The current
outbreak of SARS-CoV-2 has infected more than 28,000,000 people and killed more than …

Cancer stem cells stemness transcription factors expression correlates with breast cancer disease stage

…, E Ioannou, I Papasotiriou - Current stem cell …, 2012 - ingentaconnect.com
Cancer stem cell-like cells (CSCs) are cancer cells that have the ability of self-renewal and
differentiation into multiple malignant cell types (hierarchy). Thus, can cause relapses and …

Current perspectives on CHEK2 mutations in breast cancer

P Apostolou, I Papasotiriou - Breast Cancer: Targets and Therapy, 2017 - Taylor & Francis
Checkpoint kinase 2 (CHEK2) is a serine/threonine kinase which is activated upon DNA
damage and is implicated in pathways that govern DNA repair, cell cycle arrest or apoptosis in …

Iron chelation treatment with combined therapy with deferiprone and deferioxamine: a 12-month trial

…, NL Kelekis, E Alexopoulou, I Papasotiriou… - Blood Cells, Molecules …, 2006 - Elsevier
The simultaneous use of deferioxamine (DFO) and deferiprone (DFP) has an additive effect
in iron excretion in transfusion-dependent thalassemic patients. In a prospective study, we …

[HTML][HTML] Bacterial and fungal microflora in surgically removed lung cancer samples

P Apostolou, A Tsantsaridou, I Papasotiriou… - Journal of cardiothoracic …, 2011 - Springer
Background Clinical and experimental data suggest an association between the presence
of bacterial and/or fungal infection and the development of different types of cancer, …

[HTML][HTML] Anvirzel™ in combination with cisplatin in breast, colon, lung, prostate, melanoma and pancreatic cancer cell lines

…, J Nester, D Komiotis, I Papasotiriou - BMC Pharmacology and …, 2013 - Springer
Background Platinum derivatives are used widely for the treatment of many cancers.
However, the toxicity that is observed makes imperative the need for new drugs, or new …

[HTML][HTML] Molecular Modes of Action of an Aqueous Nerium oleander Extract in Cancer Cells In Vitro and In Vivo

…, M Dawood, WP Roos, K Franke, I Papasotiriou… - Molecules, 2023 - mdpi.com
Cancer drug resistance remains a major obstacle in clinical oncology. As most anticancer
drugs are of natural origin, we investigated the anticancer potential of a standardized cold-…

Is network meta-analysis a revolutionary statistical tool for improving the reliability of clinical trial results? A brief overview and emerging issues arising

G Beis, I Papasotiriou - in vivo, 2023 - iv.iiarjournals.org
Network meta-analysis (NMA) as the quantification of pairwise meta-analysis in a network
format has been of particular interest to medical researchers in recent years. As a powerful …