Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and Agouti-related protein mRNA levels and body weight in rats
J Kamegai, H Tamura, T Shimizu, S Ishii, H Sugihara… - Diabetes, 2001 - Am Diabetes Assoc
Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor (GHS-R), was
originally purified from the rat stomach. Like the synthetic growth hormone secretagogues (…
originally purified from the rat stomach. Like the synthetic growth hormone secretagogues (…
Ghrelin stimulates GH but not food intake in arcuate nucleus ablated rats
…, J Kamegai, T Shimizu, S Ishii, H Sugihara… - …, 2002 - academic.oup.com
Ghrelin, an endogenous ligand for the GH secretagogue receptor 1a (GHS-R 1a ), was
originally purified from the rat stomach. Ghrelin mRNA and peptide have also been detected in …
originally purified from the rat stomach. Ghrelin mRNA and peptide have also been detected in …
Central effect of ghrelin, an endogenous growth hormone secretagogue, on hypothalamic peptide gene expression
…, H Tamura, T Shimizu, S Ishii, H Sugihara… - …, 2000 - academic.oup.com
Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor (GHS-R),
was originally purified from the rat stomach. Like the synthetic GHSs, ghrelin specifically …
was originally purified from the rat stomach. Like the synthetic GHSs, ghrelin specifically …
[HTML][HTML] Hypothalamic growth hormone secretagogue receptor regulates growth hormone secretion, feeding, and adiposity
…, H Tamura, J Kamegai, H Sugihara… - The Journal of …, 2002 - Am Soc Clin Investig
Growth hormone secretagogues (GHSs) stimulate GH secretion and food intake. GHS receptor
(GHS-R) mRNA has been identified mainly in the arcuate nucleus (Arc) and ventromedial …
(GHS-R) mRNA has been identified mainly in the arcuate nucleus (Arc) and ventromedial …
Effects of insulin, leptin, and glucagon on ghrelin secretion from isolated perfused rat stomach
J Kamegai, H Tamura, T Shimizu, S Ishii, H Sugihara… - Regulatory peptides, 2004 - Elsevier
Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor, was originally
purified from the rat stomach. Although ghrelin has been recognized as an important …
purified from the rat stomach. Although ghrelin has been recognized as an important …
Role of ghrelin in streptozotocin-induced diabetic hyperphagia
…, J Kamegai, H Tamura, T Shimizu, H Sugihara… - …, 2002 - academic.oup.com
Ghrelin, an endogenous ligand for the growth hormone (GH) secretagogue receptor, was
originally purified from the rat stomach. We have previously reported that central administration …
originally purified from the rat stomach. We have previously reported that central administration …
Comparison of three α‐glucosidase inhibitors for glycemic control and bodyweight reduction in J apanese patients with obese type 2 diabetes
H Sugihara, M Nagao, T Harada… - Journal of diabetes …, 2014 - Wiley Online Library
Aims/Introduction α‐Glucosidase inhibitors (α GI s) are widely used for the primary treatment
of type 2 diabetes. We compared the clinical effects of three α GI s (miglitol, acarbose and …
of type 2 diabetes. We compared the clinical effects of three α GI s (miglitol, acarbose and …
Generation of polyclonal antiserum against the growth hormone secretagogue receptor (GHS-R): evidence that the GHS-R exists in the hypothalamus, pituitary and …
…, T Shibasaki, K Wada, I Parhar, J Kamegai, H Sugihara… - Life sciences, 2001 - Elsevier
Growth hormone (GH) secretagogues (GHSs), which stimulate GH secretion, are synthetic
compounds that act through the GHS receptor (GHS-R) which has been recently cloned. We …
compounds that act through the GHS receptor (GHS-R) which has been recently cloned. We …
[HTML][HTML] Liver fibrosis is associated with carotid atherosclerosis in patients with liver biopsy-proven nonalcoholic fatty liver disease
…, M Nagao, K Inagaki, I Fukuda, H Sugihara… - Scientific Reports, 2021 - nature.com
Nonalcoholic fatty liver disease (NAFLD) is related to subclinical atherosclerosis. However,
whether the severity of the disease (or which histopathological component) is associated …
whether the severity of the disease (or which histopathological component) is associated …
Growth hormone receptor gene is expressed in neuropeptide Y neurons in hypothalamic arcuate nucleus of rats
J Kamegai, S Minami, H Sugihara, O Hasegawa… - …, 1996 - academic.oup.com
GH feeds back on the hypothalamus and regulates its own secretion. We have previously
shown that systemic administration of GH induces expression of the c-fos gene, a marker of …
shown that systemic administration of GH induces expression of the c-fos gene, a marker of …