User profiles for HIROSHI YANO

Hiroshi Yano

- Verified email at power.bk.tsukuba.ac.jp - Cited by 3957

Hiroshi Yano

- Verified email at med.cornell.edu - Cited by 2406

[HTML][HTML] Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells.

H Yano, S Nakanishi, K Kimura, N Hanai… - Journal of Biological …, 1993 - Elsevier
The surface engagement of high affinity immunoglobulin E receptor (Fc epsilon RI) of rat
basophilic leukemia 2H3 (RBL-2H3) cells induced histamine secretion and leukotriene release …

[PDF][PDF] Interferon-γ drives Treg fragility to promote anti-tumor immunity

AE Overacre-Delgoffe, M Chikina, RE Dadey, H Yano… - Cell, 2017 - cell.com
Regulatory T cells (T regs ) are a barrier to anti-tumor immunity. Neuropilin-1 (Nrp1) is
required to maintain intratumoral T reg stability and function but is dispensable for peripheral …

Inhibitory receptors and ligands beyond PD-1, PD-L1 and CTLA-4: breakthroughs or backups

LP Andrews, H Yano, DAA Vignali - Nature immunology, 2019 - nature.com
Although immunotherapeutics targeting the inhibitory receptors (IRs) CTLA-4, PD-1 or PD-L1
have made substantial clinical progress in cancer, a considerable proportion of patients …

Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion

DV Sawant, H Yano, M Chikina, Q Zhang, M Liao… - Nature …, 2019 - nature.com
Regulatory T cells (T reg cells) maintain host self-tolerance but are a major barrier to effective
cancer immunotherapy. T reg cells subvert beneficial anti-tumor immunity by modulating …

Improved inversion channel mobility in 4H-SiC MOSFETs on Si face utilizing phosphorus-doped gate oxide

D Okamoto, H Yano, K Hirata… - IEEE Electron Device …, 2010 - ieeexplore.ieee.org
We propose a new technique for fabricating 4H-SiC metal-oxide-semiconductor field-effect
transistors (MOSFETs) with high inversion channel mobility. P atoms were incorporated into …

Oxygen reduction activity of carbon-supported Pt− M (M= V, Ni, Cr, Co, and Fe) alloys prepared by nanocapsule method

H Yano, M Kataoka, H Yamashita, H Uchida… - Langmuir, 2007 - ACS Publications
Monodispersed Pt and Pt−M (M = V, Cr, Fe, Co, and Ni) alloy nanoparticles supported on
carbon black (denoted as Pt/CB and Pt−M/CB) were prepared by the simultaneous reduction of …

The c-kit receptor ligand functions as a mast cell chemoattractant

CJ Meininger, H Yano, R Rottapel, A Bernstein… - 1992 - ashpublications.org
Mast cells accumulate at sites of neovascularization, solid tumors, and many immune reactions.
Such accumulation requires directed migration of mature mast cells or their precursors. …

[PDF][PDF] Interleukin-35 limits anti-tumor immunity

…, LP Andrews, GM Delgoffe, H Yano… - Immunity, 2016 - cell.com
Regulatory T (Treg) cells pose a major barrier to effective anti-tumor immunity. Although Treg
cell depletion enhances tumor rejection, the ensuing autoimmune sequelae limits its utility …

Inulin fibre promotes microbiota-derived bile acids and type 2 inflammation

M Arifuzzaman, TH Won, TT Li, H Yano, S Digumarthi… - Nature, 2022 - nature.com
Dietary fibres can exert beneficial anti-inflammatory effects through microbially fermented
short-chain fatty acid metabolites 1 , 2 , although the immunoregulatory roles of most fibre diets …

Droplet-based forward genetic screening of astrocyte–microglia cross-talk

…, LE Flausino, BM Andersen, V Rothhammer, H Yano… - Science, 2023 - science.org
Cell–cell interactions in the central nervous system play important roles in neurologic diseases.
However, little is known about the specific molecular pathways involved, and methods …