Decreased miR-206 expression in BRCA1 wild-type triple-negative breast cancer cells after concomitant treatment with gemcitabine and a Poly (ADP-ribose) …
…, M Tsuji, Y Udaka, H Oyamada, H Tsuchiya… - Anticancer …, 2014 - ar.iiarjournals.org
No targeted-therapy has been established for triple-negative breast cancer accompanied by
mutations in breast cancer susceptibility gene1 (BRCA1) mutation. In the present study, …
mutations in breast cancer susceptibility gene1 (BRCA1) mutation. In the present study, …
[PDF][PDF] Disabling of the erbB pathway followed by IFN-γ modifies phenotype and enhances genotoxic eradication of breast tumors
Reversion of the malignant phenotype of erbB2-transformed cells can be driven by anti-erbB2/neu
monoclonal antibodies (mAbs), which disrupt the receptor's kinase activity. We …
monoclonal antibodies (mAbs), which disrupt the receptor's kinase activity. We …
Oligonucleotide synthesis. Part 21. Synthesis of ribooligonucleotides using the 4-methoxybenzyl group as a new protecting group for the 2'-hydroxyl group
H Takaku, K Kamaike, H Tsuchiya - The Journal of Organic …, 1984 - ACS Publications
The 4-methoxybenzyl group was introduced to protect the 2'-hydroxyl group of uridine,
cytidine, and IV2-benzoylguanosine by treatment of 2', 3'-0-(dibutylstannylene) uridine or NaH-…
cytidine, and IV2-benzoylguanosine by treatment of 2', 3'-0-(dibutylstannylene) uridine or NaH-…
Eribulin upregulates miR-195 expression and downregulates Wnt3a expression in non-basal-like type of triple-negative breast cancer cell MDA-MB-231
…, M Tsuji, Y Udaka, H Oyamada, H Tsuchiya… - Human cell, 2016 - Springer
Triple-negative breast cancer (TNBC), which does not show hormone sensitivity, is a poor
prognosis disease without an established targeted treatment, so that establishing a …
prognosis disease without an established targeted treatment, so that establishing a …
[HTML][HTML] Reduced PTEN expression and overexpression of miR‑17‑5p,‑19a‑3p,‑19b‑3p,‑21‑5p,‑130b‑3p,‑221‑3p and‑222‑3p by glioblastoma stem‑like cells following …
…, Y Udaka, H Oyamada, H Tsuchiya… - Oncology …, 2015 - spandidos-publications.com
Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a tumor suppressor
gene that induces cell apoptosis by inhibiting the PI3K/Akt signaling pathway. Glioblastoma …
gene that induces cell apoptosis by inhibiting the PI3K/Akt signaling pathway. Glioblastoma …
Synthesis of 2'-or 3'-o-(4-methoxybenzyl) nucleosides and its application in the 3'-terminal nonanucleotide sequence of rous sarcoma virus 35S RNA synthesis
K Kamaike, H Tsuchiya, K Imai, H Takaku - Tetrahedron, 1986 - Elsevier
2'- or 3'-O-(4-Methoxybenzyl)nucleoside derivatives were synthesized by treatment of
uridine, N 4 -benzoylcytidine, N 6 -benzoyladenosine, and N 2 -benzoylguanosine with 4-methoxy-…
uridine, N 4 -benzoylcytidine, N 6 -benzoyladenosine, and N 2 -benzoylguanosine with 4-methoxy-…
Aggregation of aeromonas gum in aqueous solution
L Zhang, X Xu, G Jiang, H Iijima, H Tsuchiya - Polymer journal, 1999 - nature.com
Aeromonas (A) gum, a stabilizer, and thickening agent of food, is composed of xylose, mannose,
galactose, glucose, and mannuronic acid. Weight-average molecular weights M w and …
galactose, glucose, and mannuronic acid. Weight-average molecular weights M w and …
Di (2, 2, 2-trifluoroethyl) phosphonate, a new phosphorylating agent, its application in the synthesis of oligodeoxyribonucleotides by the phosphotriester approach
H Takaku, H Tsuchiya, K Imai, DE Gibbs - Chemistry Letters, 1984 - academic.oup.com
A new phosphorylating agent, di(2,2,2-trifluoroethyl) phosphonate (1) was found to be a
useful agent for the phosphorylation of 3′-hydroxyl group of deoxyribonucleosides. When 5′-O…
useful agent for the phosphorylation of 3′-hydroxyl group of deoxyribonucleosides. When 5′-O…
Specific removal of 5-chloro-8-quinolyl protecting group of internucleotidic bonds
K Kamaike, S Ueda, H Tsuchiya… - Chemical and …, 1983 - jstage.jst.go.jp
5-Chloro—8-quinolyl protecting group of internucleotidic bonds was efficiently removed by
treatment with zinc acetate or 2—pyridine—carboxaldehyde oxime at room temperature. On …
treatment with zinc acetate or 2—pyridine—carboxaldehyde oxime at room temperature. On …
Synergistic effect of IFN-γ on breast cancer targeted therapy
ErbB2 is amplified in~ 30% of breast cancer patients, and its amplification is associated with
poor prognosis and worse survival outcome. We examined the synergistic effect of interferon…
poor prognosis and worse survival outcome. We examined the synergistic effect of interferon…