Background In a previous phase 3 trial of adjuvant chemotherapy after resection of non–small-cell
lung cancer, a combination of uracil and tegafur (often referred to as UFT) taken orally …

The 41-kDa and 43-kDa mitogen-activated protein (MAP) kinases play a pivotal role in the
mitogenic signal transduction pathway and are essential components of the MAP kinase …

Thioredoxin‐2 (Trx‐2) is a mitochondria‐specific member of the thioredoxin superfamily.
Mitochondria have a crucial role in the signal transduction for apoptosis. To investigate the …

Purpose: Angiogenesis is an essential process in the progression of malignant tumors.
Whereas pan-endothelial markers, such as CD34, are generally used in evaluation of …

Purpose Recent clinical trials have shown the efficacy of platinum-based adjuvant chemotherapy
for completely resected non–small-cell lung cancer (NSCLC). In Japan, many clinical …

PURPOSE We performed a study to determine whether postoperative mild chemotherapy to
maintain the patient's quality of life (QOL) and immunoactivity could also prolong survival. …

Objective: The 30-day operative mortality for thoracotomy in lung cancer is described herein.
Methods: From January 1994 through December 1994, the Japanese Association for Chest …

PURPOSE: The aim of this study was to evaluate the relationships among [ 18 F]fluorodeoxyglucose
([ 18 F]-FDG) uptake, Glut-1 and HK-II expressions, and grade of inflammation in …

Epidermal growth factor (EGF) receptor (EGFR) signalling is implicated in tumour invasion
and metastasis 1 , 2 . However, whether there are EGFR signalling pathways specifically used …

Identification of the molecular machinery employed in cancer invasion, but not in normal adult
cells, will greatly contribute to cancer therapeutics. Here we found that an ArfGAP, AMAP1/…