Three distinct stages of apoptotic nuclear condensation revealed by time-lapse imaging, biochemical and electron microscopy analysis of cell-free apoptosis

…, K Tanda, T Suda, K Uehira, H Kanouchi… - Experimental cell …, 2007 - Elsevier
During apoptotic execution, chromatin undergoes a phase change from a heterogeneous,
genetically active network to an inert highly condensed form that is fragmented and packaged …

Antioxidant activity of vitamin B6 delays homocysteine-induced atherosclerosis in rats

N Endo, K Nishiyama, A Otsuka, H Kanouchi… - British journal of …, 2006 - cambridge.org
Elevated plasma homocysteine is a risk factor for atherosclerotic disease. In the present
study, we have examined whether the oxidative stress due to a low level of vitamin B6 …

Supplementation with branched-chain amino acids attenuates hepatic apoptosis in rats with chronic liver disease

M Kuwahata, H Kubota, H Kanouchi, S Ito, A Ogawa… - Nutrition research, 2012 - Elsevier
Branched-chain amino acids (BCAA) can function as pharmacologic nutrients for patients
with decompensated cirrhosis. However, the effects of BCAA at the early stage of chronic liver …

Association of protein and magnesium intake with prevalence of prefrailty and frailty in community-dwelling older Japanese women

…, T Takenaka, M Ohishi, H Kanouchi - Journal of nutritional …, 2021 - jstage.jst.go.jp
We examined the association between nutrient intake and prefrailty. Data from 815 older
people (63% women) who participated in a community-based health check survey (Tarumizu …

[HTML][HTML] Relationship between oral hypofunction, and protein intake: a cross-sectional study in local community-dwelling adults

K Nishi, H Kanouchi, A Tanaka, M Nakamura… - Nutrients, 2021 - mdpi.com
Few studies have investigated the relationship between nutritional status and comprehensive
assessment of oral hypofunction, especially protein intake-related sarcopenia. Thus, we …

[HTML][HTML] The association between dietary variety and physical frailty in community-dwelling older adults

…, K Tomioka, Y Taniguchi, M Kimura, H Kanouchi… - Healthcare, 2021 - mdpi.com
The aim of this cross-sectional study was to examine the association between diet variety
and physical frailty in community-dwelling older adults. Data of 577 older adults (mean age: …

Degradation of PrPSc by Keratinolytic Protease from Nocardiopsis sp. TOA-1

…, Y Moriyama, K Furukawa, H Kanouchi… - Bioscience …, 2006 - Taylor & Francis
A keratinolytic alkaline proteae (NAPase) from Nocardiopsis sp. TOA-1 degraded a scrapie
prion without any chemical or physical treatment. Optimal temperature and pH were 60 C …

Alkaline serine protease produced by Streptomyces sp. degrades PrPSc

Z Hui, H Doi, H Kanouchi, Y Matsuura, S Mohri… - Biochemical and …, 2004 - Elsevier
A PrP Sc -degrading enzyme was isolated from the culture medium of Streptomyces sp. using
perchloric acid-soluble protein (PSP) as a substrate. The media of 500 microbial species …

Vitamin B6 suppresses apoptosis of NM-1 bovine endothelial cells induced by homocysteine and copper

…, M Okabe, M Matsumoto, H Kanouchi… - … et Biophysica Acta (BBA …, 2007 - Elsevier
Hyperhomocysteinemia is an important risk factor for atherosclerosis. We previously
reported that formation of early atherosclerosis in the rat aorta was associated with …

Homocysteine and copper induce cellular apoptosis via caspase activation and nuclear translocation of apoptosis-inducing factor in neuronal cell line SH-SY5Y

…, K Nishiyama, M Matsumoto, H Kanouchi… - Neuroscience …, 2010 - Elsevier
Hyperhomocysteinemia has been implicated in dementia and neurodegenerative disease.
Physiological homocysteine concentrations did not result in apoptosis in SH-SY5Y cells in …