[HTML][HTML] Significantly altered serum levels of NAD, AGE, RAGE, CRP, and elastin as potential biomarkers of psoriasis and aging—a case-control study

…, J Krejsek, V Rehacek, M Esterkova, H Kovarikova… - Biomedicines, 2022 - mdpi.com
Background: This study aims to investigate potential markers of psoriasis and aging, and to
elucidate possible connections between these two processes. Methods: The serum samples …

[HTML][HTML] Next-Generation Sequencing Approach in Methylation Analysis of HNF1B and GATA4 Genes: Searching for Biomarkers in Ovarian Cancer

I Bubancova, H Kovarikova, J Laco, E Ruszova… - International journal of …, 2017 - mdpi.com
DNA methylation is well-known to be associated with ovarian cancer (OC) and has great
potential to serve as a biomarker in monitoring response to therapy and for disease screening. …

Deregulation of selected microRNAs in sinonasal carcinoma: value of miR‐21 as prognostic biomarker in sinonasal squamous cell carcinoma

H Kovarikova, I Bubancova, J Laco, K Sieglova… - Head & …, 2017 - Wiley Online Library
Background Tumors occurring in the sinonasal area are characterized by unfavorable outcome
due to difficult diagnosis, treatment, and prognosis of the disease corresponding with the …

MicroRNA deregulation in papillary thyroid cancer and its relationship with BRAF V600E mutation

P Celakovsky, H Kovarikova, V Chrobok, J Mejzlik… - in vivo, 2021 - iv.iiarjournals.org
Background: MicroRNAs (miRNAs) are non-coding regulatory molecules 18-25 nucleotides
in length that act as post-transcriptional regulators of gene expression. MiRNAs affect …

Identification of a four-gene methylation biomarker panel in high-grade serous ovarian carcinoma

I Baranova, H Kovarikova, J Laco… - Clinical Chemistry and …, 2020 - degruyter.com
Background The lack of effective biomarkers for the screening and early detection of ovarian
cancer (OC) is one of the most pressing problems in oncogynecology. Because epigenetic …

Identification and development of a lung adenocarcinoma PDX model with STRN-ALK fusion

…, KE Pierson, AA Nair, JI Davila, H Kovarikova… - Clinical lung cancer, 2019 - Elsevier
Gene fusions involving the anaplastic lymphoma kinase gene (ALK) often leads to oncogenic
activation of the ALK kinase resulting in tumor development in lung and other solid tumors. …

[HTML][HTML] Telomere length, oxidative and epigenetic changes in blood DNA of patients with exacerbated psoriasis vulgaris

…, K Hamakova, M Chmelarova, H Kovarikova… - Anais Brasileiros de …, 2023 - SciELO Brasil
Background The pathogenesis of psoriasis vulgaris involves changes in DNA molecules,
genomic instability, telomere attrition, and epigenetic alterations among them. These changes …

Aberrant methylation of PCDH17 gene in high-grade serous ovarian carcinoma

I Baranova, H Kovarikova, J Laco, O Dvorak… - Cancer …, 2018 - content.iospress.com
BACKGROUND: Aberrant DNA methylation of protocadherins (PCDHs) has been associated
with development and progression of various types of cancer. It could represent possible …

DNA hypermethylation of CADM1, PAX5, WT1, RARβ, and PAX6 genes in oropharyngeal cancer associated with human papillomavirus

N Birknerová, H Kovaříková, I Baranová, A Přikrylová… - Epigenetics, 2022 - Taylor & Francis
Recently, an increasing incidence of HPV-induced oropharyngeal squamous cell carcinoma
(OPSCC) has been observed. Moreover, locoregionally advanced stages require a …

MicroRNA expression in SMARCB1/INI1-deficient sinonasal carcinoma: A clinicopathological and molecular genetic study

J Laco, H Kovaříková, M Chmelařová, H Vošmiková… - Virchows Archiv, 2018 - Springer
Carcinomas of the sinonasal tract comprise of a heterogenous group of rare malignant
tumors, of which the etiopathogenesis is largely unknown. In about 20–30% of sinonasal …