[HTML][HTML] Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors

…, K Yang, F Liu, R Jiang, X Yang, T You, X Liu, X Yang… - Nature, 2020 - nature.com
A new coronavirus, known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
is the aetiological agent responsible for the 2019–2020 viral pneumonia outbreak of …

Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease

…, Y Li, F Bai, H Wang, X Cheng, X Cen, S Hu, X Yang… - Science, 2020 - science.org
SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is the etiological agent
responsible for the global COVID-19 (coronavirus disease 2019) outbreak. The main protease of …

Roton pair density wave in a strong-coupling kagome superconductor

H Chen, H Yang, B Hu, Z Zhao, J Yuan, Y Xing, G Qian… - Nature, 2021 - nature.com
The transition metal kagome lattice materials host frustrated, correlated and topological
quantum states of matter 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 – 9 . Recently, a new family of vanadium-based …

[HTML][HTML] Spin-polarized oxygen evolution reaction under magnetic field

…, X Liu, C Shen, J Gracia, HJ Gao, H Yang… - Nature …, 2021 - nature.com
The oxygen evolution reaction (OER) is the bottleneck that limits the energy efficiency of
water-splitting. The process involves four electrons’ transfer and the generation of triplet state O …

The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor

H Yang, M Yang, Y Ding, Y Liu, Z Lou… - Proceedings of the …, 2003 - National Acad Sciences
A newly identified severe acute respiratory syndrome coronavirus (SARS-CoV), is the etiological
agent responsible for the outbreak of SARS. The SARS-CoV main protease, which is a …

Structure of the RNA-dependent RNA polymerase from COVID-19 virus

…, C Zhu, T Hu, T Hua, B Zhang, X Yang, J Li, H Yang… - Science, 2020 - science.org
A novel coronavirus [severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2)] outbreak
has caused a global coronavirus disease 2019 (COVID-19) pandemic, resulting in tens …

[HTML][HTML] Structural biology of SARS-CoV-2 and implications for therapeutic development

H Yang, Z Rao - Nature Reviews Microbiology, 2021 - nature.com
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
is an unprecedented global health crisis. However, therapeutic options for …

[HTML][HTML] Multiple pathways for SARS-CoV-2 resistance to nirmatrelvir

…, Z Sheng, AC Uhlemann, SP Goff, Y Sabo, H Yang… - Nature, 2023 - nature.com
Nirmatrelvir, an oral antiviral targeting the 3CL protease of SARS-CoV-2, has been demonstrated
to be clinically useful against COVID-19 (refs. ). However, because SARS-CoV-2 has …

[HTML][HTML] Experimental observation of topological Fermi arcs in type-II Weyl semimetal MoTe2

…, H Zhang, Z Xu, J Denlinger, A Fedorov, H Yang… - Nature Physics, 2016 - nature.com
Weyl semimetal is a new quantum state of matter 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12
hosting the condensed matter physics counterpart of the relativistic Weyl fermions 13 originally …

[HTML][HTML] Research on K-value selection method of K-means clustering algorithm

C Yuan, H Yang - J, 2019 - mdpi.com
Among many clustering algorithms, the K-means clustering algorithm is widely used because
of its simple algorithm and fast convergence. However, the K-value of clustering needs to …