Autoantibody profiling as early diagnostic and prognostic tool for rheumatoid arthritis

…, H Heinzl, M Uffmann, JS Smolen, G Steiner - Annals of the …, 2005 - ard.bmj.com
Background: Early treatment prevents progression of joint damage in rheumatoid arthritis (RA),
but diagnosis in early disease is impeded by lack of appropriate diagnostic criteria. …

Therapeutic strategies for rheumatoid arthritis

JS Smolen, G Steiner - Nature reviews Drug discovery, 2003 - nature.com
Recent years have seen considerable advances in our understanding of both the clinical
and basic-research aspects of rheumatoid arthritis. Clinical progress has come from a better …

Adverse events and efficacy of TNF-α blockade with infliximab in patients with systemic lupus erythematosus: long-term follow-up of 13 patients

…, WB Graninger, RE Voll, E Rath, G Steiner… - …, 2009 - academic.oup.com
Objective. To follow-up on all available infliximab-treated SLE patients for safety and long-term
efficacy in order to extract information that is useful for planning appropriate controlled …

[HTML][HTML] Osteoclasts are essential for TNF-α–mediated joint destruction

…, M Tohidast-Akrad, G Kollias, G Steiner… - The Journal of …, 2002 - Am Soc Clin Investig
The detailed cellular and molecular mechanisms leading to joint destruction in rheumatoid
arthritis, a disease driven by proinflammatory cytokines, are still unknown. To address the …

[HTML][HTML] Rheumatoid arthritis associated autoantibodies in patients with synovitis of recent onset

…, J Hoxworth, C Yarboro, JS Smolen, G Steiner… - Arthritis Research & …, 2000 - Springer
Statement of findings An inception cohort of 238 patients having peripheral joint synovitis of
less than 12 months duration was evaluated clinically and followed prospectively for 1 year …

Anti-inflammatory and apoptotic effects of the polyphenol curcumin on human fibroblast-like synoviocytes

…, T Becker, E Dietersdorfer, H Kiener, G Steiner - International …, 2013 - Elsevier
BACKGROUND: It has recently been reported that the polyphenol curcumin has pronounced
anti-carcinogenic, anti-inflammatory and pro-apoptotic properties. This study investigated …

Activation, differential localization, and regulation of the stress‐activated protein kinases, extracellular signal–regulated kinase, c‐Jun N‐terminal kinase, and p38 …

…, JS Smolen, BJ Schmid, CW Steiner… - … : Official Journal of …, 2000 - Wiley Online Library
Objective To investigate whether stress‐ and mitogen‐activated protein kinases (SAPK/MAPK),
such as extracellular signal–regulated kinase (ERK), c‐Jun N‐terminal kinase (JNK), …

Safety and efficacy of tumor necrosis factor α blockade in systemic lupus erythematosus: an open‐label study

M Aringer, WB Graninger, G Steiner… - Arthritis & Rheumatism …, 2004 - Wiley Online Library
Objective To investigate the safety of therapeutic tumor necrosis factor α (TNFα) blockade in
patients with systemic lupus erythematosus (SLE), in whom this proinflammatory cytokine is …

Single and combined inhibition of tumor necrosis factor, interleukin‐1, and RANKL pathways in tumor necrosis factor–induced arthritis: effects on synovial …

…, C Dunstan, G Kollias, G Steiner… - … : Official Journal of …, 2004 - Wiley Online Library
Objective To investigate the efficacy of single and combined blockade of tumor necrosis factor
(TNF), interleukin‐1 (IL‐1), and RANKL pathways on synovial inflammation, bone erosion, …

Depletion of endothelial progenitor cells in the peripheral blood of patients with rheumatoid arthritis

J Grisar, D Aletaha, CW Steiner, T Kapral, S Steiner… - Circulation, 2005 - Am Heart Assoc
Background— Rheumatoid arthritis (RA) is characterized by increased cardiovascular
morbidity and mortality that cannot be explained solely by traditional cardiovascular risk factors. …