User profiles for FUMIHITO ONO

Fumihito Ono

Professor of Physiology, Osaka Medical College
Verified email at osaka-med.ac.jp
Cited by 1640

Identification of adult nephron progenitors capable of kidney regeneration in zebrafish

…, G Djordjevic, B Lichman, H Zhu, T Ikenaga, F Ono… - Nature, 2011 - nature.com
Loss of kidney function underlies many renal diseases 1 . Mammals can partly repair their
nephrons (the functional units of the kidney), but cannot form new ones 2 , 3 . By contrast, fish …

[HTML][HTML] “Slow” skeletal muscles across vertebrate species

VM Luna, E Daikoku, F Ono - Cell & bioscience, 2015 - Springer
Skeletal muscle fibers are generally classified into two groups: slow (type I) and fast (type II).
Fibers in each group are uniquely designed for specific locomotory needs based on their …

Paralytic zebrafish lacking acetylcholine receptors fail to localize rapsyn clusters to the synapse

F Ono, S Higashijima, A Shcherbatko… - Journal of …, 2001 - Soc Neuroscience
Physiological analysis of two lines of paralytic mutant zebrafish,relaxed and sofa potato,
reveals defects in distinct types of receptors in skeletal muscle. In sofa potato the paralysis …

[HTML][HTML] Voltage-dependent sodium channel function is regulated through membrane mechanics

A Shcherbatko, F Ono, G Mandel, P Brehm - Biophysical journal, 1999 - cell.com
Cut-open recordings from Xenopus oocytes expressing either nerve (PN1) or skeletal muscle
(SkM1) Na + channel α subunits revealed slow inactivation onset and recovery kinetics of …

[PDF][PDF] Tethering naturally occurring peptide toxins for cell-autonomous modulation of ion channels and receptors in vivo

…, H Wen, JM Miwa, J Xing, AB Tekinay, F Ono… - Neuron, 2004 - cell.com
The physiologies of cells depend on electrochemical signals carried by ion channels and
receptors. Venomous animals produce an enormous variety of peptide toxins with high affinity …

The nicotinic acetylcholine receptors of zebrafish and an evaluation of pharmacological tools used for their study

RL Papke, F Ono, C Stokes, JM Urban… - Biochemical …, 2012 - Elsevier
Zebrafish (Danio rerio) have been used to study multiple effects of nicotine, for example on
cognition, locomotion, and stress responses, relying on the assumption that pharmacological …

[HTML][HTML] Increased BUB1B/BUBR1 expression contributes to aberrant DNA repair activity leading to resistance to DNA-damaging agents

…, K Hirata, H Hirano, H Nomi, Y Hirose, F Ono… - Oncogene, 2021 - nature.com
There has been accumulating evidence for the clinical benefit of chemoradiation therapy (CRT),
whereas mechanisms in CRT-recurrent clones derived from the primary tumor are still …

The zebrafish motility mutant twitch once reveals new roles for rapsyn in synaptic function

F Ono, A Shcherbatko, S Higashijima… - Journal of …, 2002 - Soc Neuroscience
Upon touch, twitch once zebrafish respond with one or two swimming strokes instead of
typical full-blown escapes. This use-dependent fatigue is shown to be a consequence of a …

[HTML][HTML] Mutation in the intracellular chloride channel CLCC1 associated with autosomal recessive retinitis pigmentosa

L Li, X Jiao, I D'Atri, F Ono, R Nelson, CC Chan… - PLoS …, 2018 - journals.plos.org
We identified a homozygous missense alteration (c.75C>A, p.D25E) in CLCC1, encoding a
presumptive intracellular chloride channel highly expressed in the retina, associated with …

[HTML][HTML] Multiple alterations in glutamatergic transmission and dopamine D2 receptor splicing in induced pluripotent stem cell-derived neurons from patients with …

…, A Kasai, Y Ago, S Kida, K Takuma, F Ono… - Translational …, 2021 - nature.com
An increasing body of evidence suggests that impaired synapse development and function
are associated with schizophrenia; however, the underlying molecular pathophysiological …