User profiles for EVANGELOS MICHELAKIS
ED MichelakisUniversity of Alberta Verified email at ualberta.ca Cited by 26663 |
[HTML][HTML] A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth
The unique metabolic profile of cancer (aerobic glycolysis) might confer apoptosis resistance
and be therapeutically targeted. Compared to normal cells, several human cancers have …
and be therapeutically targeted. Compared to normal cells, several human cancers have …
Inflammation, growth factors, and pulmonary vascular remodeling
…, PL Jones, ML Maitland, ED Michelakis… - Journal of the american …, 2009 - jacc.org
Inflammatory processes are prominent in various types of human and experimental pulmonary
hypertension (PH) and are increasingly recognized as major pathogenic components of …
hypertension (PH) and are increasingly recognized as major pathogenic components of …
Oral sildenafil is an effective and specific pulmonary vasodilator in patients with pulmonary arterial hypertension: comparison with inhaled nitric oxide
E Michelakis, W Tymchak, D Lien, L Webster… - Circulation, 2002 - Am Heart Assoc
Background— The prognosis of patients with severe pulmonary hypertension (PHT) is poor.
To determine prognosis and guide therapy, an acute hemodynamic trial of selective …
To determine prognosis and guide therapy, an acute hemodynamic trial of selective …
An abnormal mitochondrial–hypoxia inducible factor-1α–Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded …
Background— The cause of pulmonary arterial hypertension (PAH) was investigated in humans
and fawn hooded rats (FHR), a spontaneously pulmonary hypertensive strain. Methods …
and fawn hooded rats (FHR), a spontaneously pulmonary hypertensive strain. Methods …
Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility
Background— Sildenafil was recently approved for the treatment of pulmonary arterial
hypertension. The beneficial effects of phosphodiesterase type 5 (PDE5) inhibitors in pulmonary …
hypertension. The beneficial effects of phosphodiesterase type 5 (PDE5) inhibitors in pulmonary …
Hypoxic pulmonary vasoconstriction
R Moudgil, ED Michelakis… - Journal of applied …, 2005 - journals.physiology.org
Humans encounter hypoxia throughout their lives. This occurs by destiny in utero, through
disease, and by desire, in our quest for altitude. Hypoxic pulmonary vasoconstriction (HPV) is …
disease, and by desire, in our quest for altitude. Hypoxic pulmonary vasoconstriction (HPV) is …
Relevant issues in the pathology and pathobiology of pulmonary hypertension
…, SC Erzurum, C Guignabert, E Michelakis… - Journal of the American …, 2013 - jacc.org
Knowledge of the pathobiology of pulmonary hypertension (PH) continues to accelerate.
However, fundamental gaps remain in our understanding of the underlying pathological …
However, fundamental gaps remain in our understanding of the underlying pathological …
Comprehensive invasive and noninvasive approach to the right ventricle–pulmonary circulation unit: state of the art and clinical and research implications
HC Champion, ED Michelakis, PM Hassoun - Circulation, 2009 - Am Heart Assoc
markers such as right atrial pressure, cardiac output, and mean PAP. 8 Importantly, this
procedure has been shown to be safe, with no deaths reported in the National Institutes of Health …
procedure has been shown to be safe, with no deaths reported in the National Institutes of Health …
Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis
…, A Haromy, K Hashimoto, ED Michelakis - Circulation …, 2004 - Am Heart Assoc
The pulmonary arteries (PA) in pulmonary arterial hypertension (PAH) are constricted and
remodeled;. They have suppressed apoptosis, partly attributable to suppression of the bone …
remodeled;. They have suppressed apoptosis, partly attributable to suppression of the bone …
Vascular endothelial growth factor gene therapy increases survival, promotes lung angiogenesis, and prevents alveolar damage in hyperoxia-induced lung injury …
B Thébaud, F Ladha, ED Michelakis, M Sawicka… - Circulation, 2005 - Am Heart Assoc
Background— Bronchopulmonary dysplasia (BPD) and pulmonary emphysema, both
significant global health problems, are characterized by a loss of alveoli. Vascular endothelial …
significant global health problems, are characterized by a loss of alveoli. Vascular endothelial …