Interleukin-6 (IL-6) is a proinflammatory cytokine that is normally tightly regulated and expressed
at low levels, except during infection, trauma, or other stress. Among several factors that …

Neoplasms have a striking tendency to metastasize or “home” to bone. Hematopoietic cells
also home to bone during embryonic development, where evidence points to the chemokine …

Cancer is a systemic disease encompassing multiple components of both tumor cells themselves
and host stromal cells. It is now clear that stromal cells in the tumor microenvironment …

With several hundred genetic diseases and an advantageous genome structure, dogs are
ideal for mapping genes that cause disease. Here we report the development of a genotyping …

Prostate cancer (CaP) forms osteoblastic skeletal metastases with an underlying osteoclastic
component. However, the importance of osteoclastogenesis in the development of CaP …

Background: Raf kinase inhibitor protein (RKIP), an inhibitor of Raf-mediated activation of
mitogen-activated protein/extracellular signal-regulated kinase kinase (MEK), is expressed at …

To delineate the role of SDF‐1 and CXCR4 in metastatic prostate cancer (CaP), positive
correlations were established between SDF‐1 levels and tumor metastasis. Neutralization of …

Tumours recruit mesenchymal stem cells to facilitate healing, which induces their conversion
into cancer-associated fibroblasts that facilitate metastasis. However, this process is poorly …

Advanced breast cancers frequently metastasize to bone, resulting in osteolytic lesions, yet
the underlying mechanisms are poorly understood. Here we report that nuclear factor–κB (NF…

Advanced prostate cancer is frequently accompanied by the development of metastasis to
bone. In the past, prostate cancer bone metastases were characterized as being osteoblastic (…