Oxygen is converted into reactive oxygen (RO) by radiation, light, the electron transport
system in mitochondria, or by other enzymes and is regulated by the action of antioxidative …

Background: To clarify the pathophysiological role of tumor-associated macrophages (TAMs),
we performed clinicopathological analysis of CD68+ cells in 70 cases of human …

Neurosteroids are de novo synthesized in the nervous system through mechanisms at least
partly independent of peripheral steroidogenic glands. However, the concept of …

Inhalation delivery of poly(lactic-co-glycolic) acid (PLGA) microspheres (MS) loaded with
the anti-tuberculosis agent rifampicin (RFP–PLGA MS) to alveolar macrophage (Mϕ) cells …

Recently, we demonstrated that cytochrome P450 side-chain cleavage enzyme (P450scc)
occurs in the rat cerebellar Purkinje cell after differentiation and remains during neonatal …

In mammals, neurosteroids are now known to be synthesized de novo in the brain as well
as other areas of the nervous system through mechanisms at least partly independent of the …

Innate immunity is a universal prophylactic system which all multi-cellular animals possess.
Macrophages are the cells that play the central role in the innate immune system. In 1991, …

It is well known that intravenous administration of lipopolysaccharide (LPS) induces severe
toxicity in mammals. The maximum tolerated dose of intravenous administration of LPS in …

Neurosteroids are now known to be synthesized de novo in the nervous system through
mechanisms at least partly independent of peripheral steroidogenic glands. In mammals, the …

Two new farnesyl phenols named grifolinones A and B, together with known grifolin and
neogrifolin, were isolated from methanolic extract of the inedible mushroom Albatrellus …