Importance BRAFmutations are reportedly associated with aggressive tumor biology.
However, in contrast with primary colorectal cancer, the association of V600E and non-…

Background Different tumor-specific prognostic factors have been identified in recent years
for patients who undergo surgery due to pancreatic head cancer, but the results often were …

Background This meta-analysis sought to evaluate the potential benefits and harms of
laparoscopic gastrectomy with D2 lymphadenectomy for locally advanced gastric cancer versus …

Objective: To evaluate the changing impact of genetic and clinicopathologic factors on
conditional overall survival (CS) over time in patients with resectable colorectal liver metastasis. …

Background Autopsy rates in Western countries consistently decline to an average of <5%,
although clinical autopsies represent a reasonable tool for quality control in hospitals, …

Importance In patients with resectable colorectal cancer liver metastases (CRLM), the
choice of surgical technique and resection margin are the only variables that are under the …

Background Innovative treatment concepts targeting essential signaling pathways may offer
new chances for patients suffering from cholangiocarcinoma ( CCC ). For that, we performed …

Background Intrahepatic cholangiocarcinoma (IHC) is a rare liver malignancy with a rising
incidence worldwide. Since no standard treatment has been established so far, the aim of this …

In colorectal cancer, oncogenic mutations transform a hierarchically organized and homeostatic
epithelium into invasive cancer tissue lacking visible organization. We sought to define …

Background Several lines of evidence indicate that Sirt1, a class III histone deacetylase (HDAC)
is implicated in the initiation and progression of malignancies and thus gained attraction …