Single-cell RNA-seq can yield valuable insights about the variability within a population of
seemingly homogeneous cells. We developed a quantitative statistical method to distinguish …

These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical aspects of …

The endothelial to haematopoietic transition (EHT) is the process whereby haemogenic
endothelium differentiates into haematopoietic stem and progenitor cells (HSPCs). The …

The emergence of new genes throughout evolution requires rewiring and extension of
regulatory networks. However, the molecular details of how the transcriptional regulation of new …

Dendritic cells (DC) are professional antigen presenting cells that develop from hematopoietic
stem cells through successive steps of lineage commitment and differentiation. Multipotent …

Alternatively primed myeloid cells predict negative outcome in leukemia. By demonstrating
that leukemia cells actively evade immune control by engaging AXL receptor tyrosine kinase …

10.7554/eLife.29312.001 Recent advances in single-cell transcriptomics techniques have
opened the door to the study of gene regulatory networks (GRNs) at the single-cell level. Here…

Most balanced chromosomal aberrations are not associated with a clinical phenotype, however,
in some patients they may disrupt gene structure. With the development of various next-…

Single‐cell sequencing experiments are a new mainstay in biology and have been advancing
science especially in the biomedical field. The high pressure to integrate the technology …

Background/Aim: Vascular anomalies encompass different vascular malformations [arteriovenous
(AVM), lymphatic (LM), venous lymphatic (VLM), venous (VM)] and vascular tumors …