Osteoarthritis is the most common joint disorder with increasing prevalence due to aging of
the population. Its multi-factorial etiology includes oxidative stress and the overproduction of …

The involvement of the RAS superfamily of monomeric GTPases in carcinogenesis is
increasingly being appreciated. A complex array of post-translational modifications and a highly …

Nuclear factor-kappaB (NF-κB) proteins constitute a family of transcription factors that are
stimulated by pro-inflammatory cytokines, chemokines, stress-related factors and extracellular …

Polycystic ovary syndrome (PCOS) is a common endocrinopathy of unknown aetiology that
affects women of reproductive age. During the past ten years, defective insulin activity in …

Polycystic ovary syndrome (PCOS) is an endocrinopathy that affects women of reproductive
age. PCOS shares components with the metabolic syndrome and has broad health …

A primary goal of bone research is to understand the mechanism(s) by which mechanical
forces dictate the cellular and metabolic activities of osteoblasts, the bone-forming cells. …

Osteoblasts are key components of the bone multicellular unit and have a seminal role in
bone remodeling, which is an essential function for the maintenance of the structural integrity …

It is well known that endothelium is the key vessel wall component in the initiation of the
atherogenic process. Its possible role in the later stages has been strongly suggested. 17, 18 …

Fibroblast growth factor-21 (FGF21) is a pleiotropic protein involved in glucose, lipid metabolism
and energy homeostasis, with main tissues of expression being the liver and adipose …

Colorectal cancer (CRC) is one of the most commonly diagnosed and lethal cancers worldwide.
It is a multistep process that requires the accumulation of genetic/epigenetic aberrations. …