Mode of action of natural and synthetic drugs against Trypanosoma cruzi and their interaction with the mammalian host

…, M Faúndez, N Galanti, A Ferreira, A Morello - … and Physiology Part A …, 2007 - Elsevier
Current knowledge of the biochemistry of Trypanosoma cruzi has led to the development of
new drugs and the understanding of their mode of action. Some trypanocidal drugs such as …

Trypanosoma cruzi: effect and mode of action of nitroimidazole and nitrofuran derivatives

…, JA Squella, Y Repetto, A Morello… - Biochemical …, 2003 - Elsevier
With the aim of determining the actual target(s) of nitro-group bearing compounds considered
as possible leads for the development of drugs against Chagas’ disease, we studied in …

Novel antitrypanosomal agents based on palladium nitrofurylthiosemicarbazone complexes: DNA and redox metabolism as potential therapeutic targets

…, C Olea-Azar, JD Maya, A Morello… - Journal of medicinal …, 2006 - ACS Publications
In the search for new therapeutic tools against American Trypanosomiasis palladium
complexes with bioactive nitrofuran-containing thiosemicarbazones as ligands were obtained. …

Trypanosoma cruzi: activities of lapachol and α-and β-lapachone derivatives against epimastigote and trypomastigote forms

…, U Kemmerling, J Ferreira, JD Maya, A Morello - Bioorganic & medicinal …, 2008 - Elsevier
Derivatives of natural quinones with biological activities, such as lapachol, α- and β-lapachones,
have been synthesized and their trypanocidal activity evaluated in vitro in Trypanosoma …

Natural and synthetic naphthoquinones active against Trypanosoma cruzi: an initial step towards new drugs for Chagas disease

CO Salas, M Faúndez, A Morello… - Current medicinal …, 2011 - ingentaconnect.com
Chagas disease is one of the most important endemic diseases in Latin America, caused by
Trypanosoma cruzi. The drugs used for the treatment of this disease, nifurtimox and …

Antiproliferative and uncoupling effects of delocalized, lipophilic, cationic gallic acid derivatives on cancer cell lines. Validation in vivo in singenic mice

…, E Parra, MI Becker, A Morello… - Journal of medicinal …, 2014 - ACS Publications
Tumor cells principally exhibit increased mitochondrial transmembrane potential (ΔΨ m ) and
altered metabolic pathways. The therapeutic targeting and delivery of anticancer drugs to …

Indazole N-oxide derivatives as antiprotozoal agents: Synthesis, biological evaluation and mechanism of action studies

…, C Olea-Azar, C Rigol, JD Maya, A Morello… - Bioorganic & medicinal …, 2006 - Elsevier
A series of indazole N-oxide derivatives have been synthesized and their antichagasic and
leishmanocidal properties studied. 3-Cyano-2-(4-iodophenyl)-2H-indazole N 1 -oxide …

Effects of nifurtimox and benznidazole upon glutathione and trypanothione content in epimastigote, trypomastigote and amastigote forms of Trypanosoma cruzi.

…, M Agosín, JM Ojeda, R Tellez, C Gaule, A Morello - 1997 - cabidigitallibrary.org
Levels of free thiols (glutathione, glutathionyl-spermidine and trypanothione) were determined
in 3 strains of Trypanosoma cruzi trypomastigotes (LQ, Dm28c Clone and Brener Clone) …

[HTML][HTML] Chagas disease: Present status of pathogenic mechanisms and chemotherapy

…, U Kemmerling, R López-Muñoz, A Morello - Biological …, 2010 - SciELO Chile
There are approximately 7.8 million people in Latin America, including Chile, who suffer from
Chagas disease and another 28 million who are at risk of contracting it. Chagas is caused …

Buthionine Sulfoximine Increases the Toxicity of Nifurtimox and Benznidazole to Trypanosoma cruzi

…, C Seguel, J Ferreira, M Pavani, A Morello… - Antimicrobial agents …, 2005 - Am Soc Microbiol
l-Buthionine (S,R)-sulfoximine (BSO) increased the toxicity of nifurtimox and benznidazole
toward the epimastigote, trypomastigote, and amastigote forms of Trypanosoma cruzi. BSO at …