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15369176,16277008,17316075,15750616,12655784,10492161,10871749,12600239,18097469,16277013,10465100,17203769,12571645,7780953,9578839,17013569,11474496,18699723,1651155,10644056,18996183,12520356,15878107,16438889,12014807,19545790,10900424,18613255,17225944,17436562,15870940,11121210,16019933,12396250,17973554,15726516,12762478,16506247,11873523,17729160,19024650,15726515,21248791,11023599,15726519,19576646,17317115,21466381,3006268,22024837,18762261,8381976,21048794,19327910,20298121,15936573,19433340,16019934,3031722,9874286,16969492,11215309,20006734,24932534,16896593,14967442,16860592,15380569,16904964,9989524,16102264,22841020,19539750,17869666,16758471,17214057,16239289,12600447,16490870,16243832,15744147,10869487,16618754,10221847,2991972,16288041,17765885,16253773,14635262,16710346,15523103,15450734,17349848,15698498,17344590,19293248,17409430,17574826,21292239,16256229,16297717,12426235,15875769,12577247,9166544,24459009,3526388,14565825,14522921,12425136,19914272,2845467,15007249,2826838,17715021,25768249,15305314,1660165,22330992,20637981,11241326,8248486,15001267,12174293,2984715,19947173,26530759,6490582,12690516,14762664,15113049,27806643,9627805,1313740,15054734,11304441,29634396,2179176,1656482,15281241,22727792,24989296,12080624,8248845,3123443,22842372,10440112,14613902,9747836,12050695,12820317,3958754,8392213,20133969,12929593,25398796,23865954,15222985,2153989,8427959,17385823,6304804,10584139,8327664,7997522,185172,15597168,21768702,20644068,27282278,6380000,8204958,10730881,11571017,12139708,26789701,31063799,12820325,12829021,3186941,12182998,23510242,2847226,8397428,20334517,14991205,7652170,23794219,3029800,1795070,2865003,23614651,2633335,9525500,14751519,6088935,23718176,2844397,6679900,28258409,3033737,18439041,20137295,20888178,9595937,19584147,7570301,15337566,15015583,6344128,8763861,12792989,8746592,9650622,1815346,19652935,3423218,22047459,6272925,15164799,8052701,19961774,1408687,12417075,1315129,15064017,23721109,11258848,20668303,8783668,990512,8896581,16540396,12851356,10557081,26263537,1496455,3013816,6647777,17318564,2349374,14761851,8971185,30806333,24060314,21887413,12548972,24754562,1767018,10190499,6320252,19708782,21039033,3802086,24925768,12661984,26148616,17723002,1349335,12767013,3969442,26907915,15708273,23000060,22000579,25427160,6251511,1305086,7838104,21899432,9813610,3787456,6538984,20726721,1584384,15624308,26514442,25578653,6296910,7416735,37157191,12508537,9973086,6251580,30092334,20148700,1657841,24485785,27043482,6330789,29528769,11155333,2596781,2320753,27381608,16308914,25030610,3809387,36253091,19215822,22949588,12139711,21164038,8155393,8955714,2451136,29497792,22197226,2685389,27542813,33809054,12450105,28668617,3764673,7100513,6308381,24528043,6387775,1519159,26791799,10073664,2562120,31683613,21952314,3909209,28517962,20699603,28804533,12678980,26173354,8532510,11537017,18173838,23628498,12883748,23862693,31095445,33359537,8276438,23295952,19580494,21119222,25432325,8316625,30135147,34208819,8210328,6294725,29675597,2897858,26473391,7775833,8514539,1305087,16298938,12466639,7713779,7478958,25808704,463049,8040027,28714550,3828524,7821113,20638195,15001276,11304443,21707226,7243541,28024724,1734589,28403142,29268056,7881883,23243068,23006987,28243283,4756298,28323577,6461395,16910775,17103218,155632,27649604,7708957,31705151,2342590,24929166,14530162,29663036,6250188,2792450,11776255,4037491,7797591,7413950,808830,7928493,25890574,33833270,6817854,29784026,30689028,213406,8789320,2745184,19267542,6977828,8326147,6094196,25891493,11885257,2020754,6461396,11098859,22021678,1479303,8469752,15629588,20584581,9747835,6000673,27130791,34381764,27459704,27135969,19540915,28340212,7216857,17301426,7480825,7948378,7134461,7220801,27222438,3766705,2071044,9421148,7871396,1485915,25351168,12139710,11198219,3949572,31287351,4068944,26785339,25964561,3671771,22739006,26680986,22665736,4960614,6282111,29053803,31341340,28326646,23273331,26064973,2994380,19393129,25159192,32234887,9702119,21128791,19703553,17352230,2292356,18259790,22958932,15053150,27643935,8073119,10490757,22691970,23804327,15810527,5977164,28516399,21155285,1685035,8311718,37044326,24460802,6857745,10757318,4130872,19823008,23000443,1290700,36455263,10524432,8089626,31047163,31180624,33332781,27250885,28607932,17726456,2239816,6266671,7613035,26332916,32218158,381510,31840756,12841601,24980658,24490283,32853385,26019540,30150422,6985173,11348424,6424895,6505271,26414508,9004352,23160669,14733636,3628739,34233299,22420966,2710944,2430315,17393633,16778110,3019970,19809542,32127788,1338281,2998530,29063166,5139623,27136365,26692028,21529309,35147734,16436114,2334576,7063642,1618676,1013316,4019274,9730275,4780343,6255509,3671770,6685380,28344789,29149089,233361,8980656,6250189,18480592,28186468,19779106,29359989,6680220,2867633,23407611,29796814,27566077,30821089,29518913,12510793,1347070,19179476,4173211,11668964,25269891,30642117,28286865,2564041,21566935,31750267,22568958,33730127,3379457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Intraoral manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) radioprotective gene therapy decreases ionizing irradiation-induced murine mucosal cell cycling and apoptosis.

Epperly MW, Carpenter M, Agarwal A, Mitra P, Nie S, Greenberger JS. Epperly MW, et al. In Vivo. 2004 Jul-Aug;18(4):401-10. In Vivo. 2004. PMID: 15369176 Free article.

Protection of esophageal multi-lineage progenitors of squamous epithelium (stem cells) from ionizing irradiation by manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) gene therapy.

Niu Y, Shen H, Epperly M, Zhang X, Nie S, Cao S, Greenberger JS. Niu Y, et al. In Vivo. 2005 Nov-Dec;19(6):965-74. In Vivo. 2005. PMID: 16277008 Free article.

Effects of MnSOD-plasmid liposome gene therapy on antioxidant levels in irradiated murine oral cavity orthotopic tumors.

Epperly MW, Wegner R, Kanai AJ, Kagan V, Greenberger EE, Nie S, Greenberger JS. Epperly MW, et al. Radiat Res. 2007 Mar;167(3):289-97. doi: 10.1667/RR0761.1. Radiat Res. 2007. PMID: 17316075

Inhalation delivery of manganese superoxide dismutase-plasmid/liposomes protects the murine lung from irradiation damage.

Carpenter M, Epperly MW, Agarwal A, Nie S, Hricisak L, Niu Y, Greenberger JS. Carpenter M, et al. Gene Ther. 2005 Apr;12(8):685-93. doi: 10.1038/sj.gt.3302468. Gene Ther. 2005. PMID: 15750616

Manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) intratracheal gene therapy reduction of irradiation-induced inflammatory cytokines does not protect orthotopic Lewis lung carcinomas.

Guo H, Epperly MW, Bernarding M, Nie S, Gretton J, Jefferson M, Greenberger JS. Guo H, et al. In Vivo. 2003 Jan-Feb;17(1):13-21. In Vivo. 2003. PMID: 12655784

Prevention of irradiation-induced esophagitis by plasmid/liposome delivery of the human manganese superoxide dismutase transgene.

Stickle RL, Epperly MW, Klein E, Bray JA, Greenberger JS. Stickle RL, et al. Radiat Oncol Investig. 1999;7(4):204-17. doi: 10.1002/(SICI)1520-6823(1999)7:4<204::AID-ROI2>3.0.CO;2-S. Radiat Oncol Investig. 1999. PMID: 10492161

Intratracheal injection of manganese superoxide dismutase (MnSOD) plasmid/liposomes protects normal lung but not orthotopic tumors from irradiation.

Epperly MW, Defilippi S, Sikora C, Gretton J, Kalend A, Greenberger JS. Epperly MW, et al. Gene Ther. 2000 Jun;7(12):1011-8. doi: 10.1038/sj.gt.3301207. Gene Ther. 2000. PMID: 10871749

Prevention of radiation-induced oral cavity mucositis by plasmid/liposome delivery of the human manganese superoxide dismutase (SOD2) transgene.

Guo H, Seixas-Silva JA Jr, Epperly MW, Gretton JE, Shin DM, Bar-Sagi D, Archer H, Greenberger JS. Guo H, et al. Radiat Res. 2003 Mar;159(3):361-70. doi: 10.1667/0033-7587(2003)159[0361:porioc]2.0.co;2. Radiat Res. 2003. PMID: 12600239

Intraesophageal MnSOD-plasmid liposome enhances engraftment and self-renewal of bone marrow derived progenitors of esophageal squamous epithelium.

Niu Y, Epperly MW, Shen H, Smith T, Wang H, Greenberger JS. Niu Y, et al. Gene Ther. 2008 Mar;15(5):347-56. doi: 10.1038/sj.gt.3303089. Epub 2007 Dec 20. Gene Ther. 2008. PMID: 18097469

MnSOD-plasmid liposome gene therapy decreases ionizing irradiation-induced lipid peroxidation of the esophagus.

Epperly MW, Tyurina YY, Nie S, Niu YY, Zhang X, Kagan V, Greenberger JS. Epperly MW, et al. In Vivo. 2005 Nov-Dec;19(6):997-1004. In Vivo. 2005. PMID: 16277013 Free article.

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