Review: The Role of Insulin-like Growth Factor-1 Signaling Pathways in Uterine Leiomyoma

In Vivo. 2015 Nov-Dec;29(6):637-49.

Abstract

A growing body of evidence suggests the association of the IGF-I bio-regulatory system with leiomyoma occurrence and growth. The complex interplay between IGF-I/IGF-IR and hormonal and other growth factors is, thus, now receiving significant attention. Elucidation of the molecular mechanisms driving the disease may allow for development of novel targeted-therapeutic strategies for the treatment of leiomyomas. Herein, we provide a concise update and overview of the function and regulation of IGF-I and its role in leiomyoma growth.

Keywords: IGFs; Leiomyomas; estrogen receptor; progesterone receptor; review.

Publication types

  • Review

MeSH terms

  • Estrogen Receptor alpha / genetics
  • Estrogen Receptor alpha / metabolism
  • Humans
  • Insulin-Like Growth Factor I / genetics*
  • Insulin-Like Growth Factor I / metabolism
  • Leiomyoma / genetics*
  • Leiomyoma / metabolism
  • Leiomyoma / pathology
  • Receptor, IGF Type 1 / genetics
  • Receptor, IGF Type 1 / metabolism
  • Receptors, Progesterone / genetics
  • Receptors, Progesterone / metabolism
  • Signal Transduction*

Substances

  • Estrogen Receptor alpha
  • Receptors, Progesterone
  • Insulin-Like Growth Factor I
  • Receptor, IGF Type 1