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Page 1
MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I.
Brägelmann J, Lorenz C, Borchmann S, Nishii K, Wegner J, Meder L, Ostendorp J, Ast DF, Heimsoeth A, Nakasuka T, Hirabae A, Okawa S, Dammert MA, Plenker D, Klein S, Lohneis P, Gu J, Godfrey LK, Forster J, Trajkovic-Arsic M, Zillinger T, Haarmann M, Quaas A, Lennartz S, Schmiel M, D'Rozario J, Thomas ES, Li H, Schmitt CA, George J, Thomas RK, von Karstedt S, Hartmann G, Büttner R, Ullrich RT, Siveke JT, Ohashi K, Schlee M, Sos ML. Brägelmann J, et al. Among authors: hirabae a. Nat Commun. 2021 Sep 17;12(1):5505. doi: 10.1038/s41467-021-25728-8. Nat Commun. 2021. PMID: 34535668 Free PMC article.
PD-1 blockade augments CD8+ T cell dependent antitumor immunity triggered by Ad-SGE-REIC in Egfr-mutant lung cancer.
Nakasuka T, Ohashi K, Nishii K, Hirabae A, Okawa S, Tomonobu N, Takada K, Ando C, Watanabe H, Makimoto G, Ninomiya K, Fujii M, Kubo T, Ichihara E, Hotta K, Tabata M, Kumon H, Maeda Y, Kiura K. Nakasuka T, et al. Among authors: hirabae a. Lung Cancer. 2023 Apr;178:1-10. doi: 10.1016/j.lungcan.2023.01.018. Epub 2023 Feb 1. Lung Cancer. 2023. PMID: 36753780
CD8+ T-cell Responses Are Boosted by Dual PD-1/VEGFR2 Blockade after EGFR Inhibition in Egfr-Mutant Lung Cancer.
Nishii K, Ohashi K, Tomida S, Nakasuka T, Hirabae A, Okawa S, Nishimura J, Higo H, Watanabe H, Kano H, Ando C, Makimoto G, Ninomiya K, Kato Y, Kubo T, Ichihara E, Hotta K, Tabata M, Toyooka S, Udono H, Maeda Y, Kiura K. Nishii K, et al. Among authors: hirabae a. Cancer Immunol Res. 2022 Sep 1;10(9):1111-1126. doi: 10.1158/2326-6066.CIR-21-0751. Cancer Immunol Res. 2022. PMID: 35802887 Free article.
CDK4/6 signaling attenuates the effect of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors in EGFR-mutant non-small cell lung cancer.
Hara N, Ichihara E, Kano H, Ando C, Morita A, Nishi T, Okawa S, Nakasuka T, Hirabae A, Abe M, Asada N, Ninomiya K, Makimoto G, Fujii M, Kubo T, Ohashi K, Hotta K, Tabata M, Maeda Y, Kiura K. Hara N, et al. Among authors: hirabae a. Transl Lung Cancer Res. 2023 Oct 31;12(10):2098-2112. doi: 10.21037/tlcr-23-99. Epub 2023 Oct 26. Transl Lung Cancer Res. 2023. PMID: 38025818 Free PMC article.
A case of interstitial pneumonia associated with systemic sclerosis and primary peritoneal serous carcinoma successfully treated with cyclophosphamide.
Kawamura S, Kubo T, Takada K, Sunami R, Okawa S, Iwamoto Y, Hirabae A, Taniguchi A, Maeda Y, Kiura K, Tabata M. Kawamura S, et al. Among authors: hirabae a. Int Cancer Conf J. 2021 Mar 16;10(3):197-200. doi: 10.1007/s13691-021-00475-1. eCollection 2021 Jul. Int Cancer Conf J. 2021. PMID: 34221831 Free PMC article.
VEGFR2 blockade augments the effects of tyrosine kinase inhibitors by inhibiting angiogenesis and oncogenic signaling in oncogene-driven non-small-cell lung cancers.
Watanabe H, Ichihara E, Kayatani H, Makimoto G, Ninomiya K, Nishii K, Higo H, Ando C, Okawa S, Nakasuka T, Kano H, Hara N, Hirabae A, Kato Y, Ninomiya T, Kubo T, Rai K, Ohashi K, Hotta K, Tabata M, Maeda Y, Kiura K. Watanabe H, et al. Among authors: hirabae a. Cancer Sci. 2021 May;112(5):1853-1864. doi: 10.1111/cas.14801. Epub 2021 Mar 18. Cancer Sci. 2021. PMID: 33410241 Free PMC article.