We report the first case of an angiomyomatous hamartoma of the inguinal lymph node with a significant adipose tissue component. The presence of a mixture of smooth muscle cells, blood vessels and adipose tissue, haphazardly arranged within a fibrous background, extending from the hilar region to the lymph node cortex, provides morphologic evidence of the hamartomatous nature of the lesion. We think that the term "angiomyolipomatous hamartoma" is more appropriate for such a lymph node lesion.