Abstract
Two new naphthoquinones, rhinacanthin-C (1) and rhinacanthin-D (2), exhibit inhibitory activity against cytomegalovirus (CMV), with EC50 values of 0.02 and 0.22 microgram/mL, respectively, against human CMV. They were isolated from the medicinal plant Rhinacanthus nasutus (Acanthaceae). The structures of the compounds were determined by analysis of their spectroscopic data, in particular, 2D NMR.
MeSH terms
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Antiviral Agents / chemistry
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Antiviral Agents / isolation & purification*
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Antiviral Agents / pharmacology
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Chemical Fractionation
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Cytomegalovirus / drug effects*
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Humans
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Lethal Dose 50
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Naphthoquinones / chemistry
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Naphthoquinones / isolation & purification*
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Naphthoquinones / pharmacology
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology
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Plants, Medicinal*
Substances
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Antiviral Agents
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Naphthoquinones
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Plant Extracts