Abstract
Three interleukins with distinct functions, IL-4, IL-5 and IL-6, are involved in the regulation of B cell response into antibody producing cells. The studies with recombinant interleukins, however, demonstrated that the activities of these interleukins were not restricted to B lineage cells but showed a wide variety of biological functions on various tissues and cells. One of the most typical example of multifunctional interleukins is IL-6. It acts not only on B cells as B cell differentiation factor but also on T cells, hematopoietic stem cells, hepatocytes, nerve cells and myeloma cells. Deregulation of the expression of these interleukins was shown to be responsible for various diseases, such as i) IL-4 vs. immediate type hypersensitivity and ii) IL-6 vs. autoimmunity and multiple myelomas.
MeSH terms
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Animals
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Antibody Formation
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Antigens, CD / chemistry
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Antigens, CD / genetics
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Antigens, CD / physiology
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B-Lymphocytes / immunology*
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Cells, Cultured
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Humans
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Immune System Diseases / immunology
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Immune System Diseases / physiopathology
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Interleukin-4 / physiology*
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Interleukin-5 / physiology*
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Interleukin-6 / physiology*
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Lymphocyte Activation / physiology
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Lymphocyte Cooperation / physiology*
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Mice
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Models, Immunological
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Multigene Family
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Multiple Myeloma / immunology
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Multiple Myeloma / pathology
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Plasmacytoma / immunology
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Plasmacytoma / pathology
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Receptors, Interleukin / chemistry
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Receptors, Interleukin / genetics
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Receptors, Interleukin / physiology
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Receptors, Interleukin-6
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Tumor Cells, Cultured
Substances
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Antigens, CD
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Interleukin-5
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Interleukin-6
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Receptors, Interleukin
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Receptors, Interleukin-6
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Interleukin-4