Metastatic prostate cancer is unique in its ability to induce the osteoblastic reaction in skeleton. This phenomenon is probably the result of complex paracrine/autocrine cell interaction between prostate cancer cells and bone cells at the metastatic sites. Recently the use of various in vivo and in vitro systems made possible the confirmation of certain cellular interactions that may participate in this process. The role of IGFs/GFBPs, urokinase-type plasminogen activator (uPA), as well as of TGF beta 1 and glucocorticoids is discussed in this review.