Abstract
The gene loci CDK4, GLI, CHOP and MDM2 have been mapped to the q13-q15 region of chromosome 12. Using fluorescence in situ hybridization onto simultaneously DAPI-banded metaphase chromosomes and interphase nuclei, we have more precisely mapped and ordered these loci, together with a number of Genethon microsatellite markers. GLI and CHOP localize to 12q13.3-14.1, CDK4 to 12q14 and MDM2 to 12q14.3-q15, and the gene order is cen-GLI/CHOP-CDK4-MDM2. The Genethon microsatellites D12S80 and D12S83 flank MDM2.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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CCAAT-Enhancer-Binding Proteins*
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Chromosome Mapping
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Chromosomes, Human, Pair 12*
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Cyclin-Dependent Kinase 4
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Cyclin-Dependent Kinases*
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DNA-Binding Proteins / genetics*
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Genetic Markers / genetics
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Humans
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In Situ Hybridization, Fluorescence
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Nuclear Proteins*
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Oncogene Proteins / genetics*
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Protein Serine-Threonine Kinases / genetics*
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Proto-Oncogene Proteins / genetics*
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Proto-Oncogene Proteins c-mdm2
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Trans-Activators
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Transcription Factor CHOP
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Transcription Factors / genetics*
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Zinc Finger Protein GLI1
Substances
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CCAAT-Enhancer-Binding Proteins
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DDIT3 protein, human
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DNA-Binding Proteins
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Genetic Markers
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Nuclear Proteins
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Oncogene Proteins
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Proto-Oncogene Proteins
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Trans-Activators
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Transcription Factors
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Zinc Finger Protein GLI1
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Transcription Factor CHOP
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MDM2 protein, human
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Proto-Oncogene Proteins c-mdm2
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Protein Serine-Threonine Kinases
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CDK4 protein, human
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Cyclin-Dependent Kinase 4
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Cyclin-Dependent Kinases