Sister-chromatid exchanges in epileptic patients on anticonvulsant therapy

S Sardaş; M Ada; A E Karakaya; N Aydin

doi:10.1016/0165-1161(94)90029-9

Sister-chromatid exchanges in epileptic patients on anticonvulsant therapy

Mutat Res. 1994 Aug;313(1):21-4. doi: 10.1016/0165-1161(94)90029-9.

Authors

S Sardaş¹, M Ada, A E Karakaya, N Aydin

Affiliation

¹ University of Gazi, Department of Toxicology, Faculty of Pharmacy, Ankara, Turkey.

PMID: 7519307
DOI: 10.1016/0165-1161(94)90029-9

Abstract

Sister-chromatid exchanges (SCE) have been studied to analyze genotoxic effects in epileptic patients on anticonvulsant therapy. All patients had an increased frequency of SCE per metaphase (p < 0.001) compared to controls, indicating a genotoxic effect of anticonvulsant drugs.

MeSH terms

Adolescent
Adult
Anticonvulsants / adverse effects*
Child
Chromosome Aberrations / chemically induced
Chromosome Aberrations / genetics*
Chromosome Disorders
Epilepsy / drug therapy*
Female
Humans
Male
Sister Chromatid Exchange*

Substances

Anticonvulsants