Abstract
Nalidixic acid, novobiocin, oxolinic acid and nitrofurantoin, each at low concentrations, cause filamentation of Gram-negative bacilli. Filamentation induced by beta-lactam antibiotics has been correlated to the binding of these antibiotics to specific penicillin-binding proteins (PBPs) of the envelope of Gram-negative bacilli. The studies reported herein indicate that the former group of non-beta-lactam antibiotics do not bind to any of the PBPs of Escherichia coli. However, PBP 1a, PBP 4 and PBP 5/6 of the filaments induced by these agents are increased significantly.
MeSH terms
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Acyltransferases / metabolism*
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Anti-Infective Agents, Urinary / pharmacology*
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Bacterial Proteins*
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Carrier Proteins / metabolism*
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Escherichia coli / cytology
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Escherichia coli / drug effects
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Escherichia coli / metabolism*
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Hexosyltransferases / metabolism*
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Multienzyme Complexes / metabolism*
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Muramoylpentapeptide Carboxypeptidase / metabolism*
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Nalidixic Acid / pharmacology*
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Nitrofurantoin / pharmacology
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Novobiocin / pharmacology
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Oxolinic Acid / pharmacology
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Penicillin-Binding Proteins
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Penicillins / metabolism
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Peptidyl Transferases / metabolism*
Substances
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Anti-Infective Agents, Urinary
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Bacterial Proteins
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Carrier Proteins
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Multienzyme Complexes
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Penicillin-Binding Proteins
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Penicillins
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Novobiocin
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Nalidixic Acid
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Nitrofurantoin
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Acyltransferases
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Peptidyl Transferases
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Hexosyltransferases
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Muramoylpentapeptide Carboxypeptidase
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Oxolinic Acid