Neutrophils create a fertile soil for metastasis

Kevin Kos; Karin E de Visser

doi:10.1016/j.ccell.2021.01.009

Neutrophils create a fertile soil for metastasis

Cancer Cell. 2021 Mar 8;39(3):301-303. doi: 10.1016/j.ccell.2021.01.009. Epub 2021 Jan 28.

Authors

Kevin Kos¹, Karin E de Visser²

Affiliations

¹ Division of Tumor Biology & Immunology, Oncode Institute, Netherlands Cancer Institute, Amsterdam, the Netherlands.
² Division of Tumor Biology & Immunology, Oncode Institute, Netherlands Cancer Institute, Amsterdam, the Netherlands; Department of Immunology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: k.d.visser@nki.nl.

PMID: 33513347
DOI: 10.1016/j.ccell.2021.01.009

Abstract

Neutrophils can facilitate the metastatic spread of cancer; however, how neutrophils are activated at metastatic sites remains poorly understood. In this issue, Xiao et al. demonstrate that the protease cathepsin C, secreted by breast cancer cells, triggers neutrophils to form neutrophil extracellular traps in the metastatic niche, thereby promoting lung metastasis.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Extracellular Traps*
Humans
Lung Neoplasms*
Neutrophils
Soil

Substances

Soil