Radiation-induced skin injury: pathogenesis, treatment, and management

Aging (Albany NY). 2020 Nov 16;12(22):23379-23393. doi: 10.18632/aging.103932. Epub 2020 Nov 16.

Abstract

Radiation-induced skin injury (RSI) refers to a frequently occurring complication of radiation therapy. Nearly 90% of patients having received radiation therapy underwent moderate-to-severe skin reactions, severely reducing patients' quality of life and adversely affecting their disease treatment. No gold standard has been formulated for RSIs. In the present study, the mechanism of RSI and topical medications was discussed. Besides, this study can be referenced for clinicians to treat RSIs to guide subsequent clinical medicine.

Keywords: radiation; skin injury.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Administration, Cutaneous
  • Animals
  • Apoptosis / drug effects
  • Dermatologic Agents / administration & dosage*
  • Dermatologic Agents / adverse effects
  • Fibrosis
  • Humans
  • Occupational Exposure / adverse effects
  • Radiation Exposure / adverse effects
  • Radiodermatitis / diagnosis
  • Radiodermatitis / drug therapy*
  • Radiodermatitis / etiology
  • Radiodermatitis / metabolism
  • Radiotherapy / adverse effects
  • Severity of Illness Index
  • Skin / drug effects*
  • Skin / metabolism
  • Skin / pathology
  • Treatment Outcome

Substances

  • Dermatologic Agents