Abstract
In this study, we designed and synthesized organelle-targeted cell-penetrating peptide (CPP)-conjugated boron compounds to increase their cellular uptake and to control the intracellular locations for the induction of sophisticated anticancer biological activity in boron neutron capture therapy (BNCT), leading to anticancer effects with ATP reduction and apoptosis when irradiated with neutrons in an in vitro BNCT assay.
MeSH terms
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Adenosine Triphosphate / antagonists & inhibitors
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Adenosine Triphosphate / metabolism
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Apoptosis / drug effects
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Boron Compounds / chemistry*
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Boron Neutron Capture Therapy*
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Cell-Penetrating Peptides / chemistry*
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Drug Delivery Systems*
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Drug Screening Assays, Antitumor
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Glioma / drug therapy*
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Glioma / pathology
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Humans
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Organelles / chemistry
Substances
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Antineoplastic Agents
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Boron Compounds
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Cell-Penetrating Peptides
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Adenosine Triphosphate