We report the case of a 20-year-old man who presented with a large heterogeneous mass incidentally found on a chest roentgenogram performed in the context of acute onset of fever and cough. A chest computed tomography scan showed a large heterogenous mass in the anterior mediastinum. The patient underwent surgical resection by a right video-assisted thoracoscopic approach. The resected mass was completely encapsulated and was histologically determined to be a lipofibroadenoma. Complete resection is curative. This is the sixth reported case of lipofibroadenoma of the thymus in the English literature and the first reported case of video-assisted thoracoscopic resection of a lipofibroadenoma.
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