NOP14 suppresses breast cancer progression by inhibiting NRIP1/Wnt/β-catenin pathway

Oncotarget. 2015 Sep 22;6(28):25701-14. doi: 10.18632/oncotarget.4573.

Abstract

NOP14, which is functionally conserved among eukaryotes, has been implicated in cancer development. Here, we show that NOP14 is poorly expressed in breast cancer cells and invasive breast cancer tissues. In vivo and in vitro studies indicated that NOP14 suppressed the tumorigenesis and metastasis of breast cancer cells. Further investigations revealed that NOP14 enhanced ERα expression and inhibited the Wnt/β-catenin pathway by up-regulating NRIP1 expression. Survival analysis indicated that low NOP14 expression was significantly associated with poor overall survival (P = 0.0006) and disease-free survival (P = 0.0007), suggesting that NOP14 is a potential prognostic factor in breast cancer. Taken together, our findings reveal that NOP14 may suppress breast cancer progression and provide new insights into the development of targeted therapeutic agents for breast cancer.

Keywords: NOP14; NRIP1; Wnt/β-catenin pathway; breast cancer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptor Proteins, Signal Transducing / genetics
  • Adaptor Proteins, Signal Transducing / metabolism*
  • Adult
  • Animals
  • Biomarkers, Tumor / genetics
  • Biomarkers, Tumor / metabolism*
  • Breast Neoplasms / genetics
  • Breast Neoplasms / metabolism*
  • Breast Neoplasms / mortality
  • Breast Neoplasms / pathology
  • Breast Neoplasms / therapy
  • Cell Movement
  • Cell Proliferation
  • Disease-Free Survival
  • Estrogen Receptor alpha / metabolism
  • Female
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Kaplan-Meier Estimate
  • MCF-7 Cells
  • Mice, Nude
  • Neoplasm Invasiveness
  • Nuclear Proteins / genetics
  • Nuclear Proteins / metabolism*
  • Nuclear Receptor Interacting Protein 1
  • RNA Interference
  • Time Factors
  • Transfection
  • Tumor Burden
  • Wnt Signaling Pathway*
  • beta Catenin / metabolism*

Substances

  • Adaptor Proteins, Signal Transducing
  • Biomarkers, Tumor
  • CTNNB1 protein, human
  • ESR1 protein, human
  • Estrogen Receptor alpha
  • NOP14 protein, human
  • Nrip1 protein, mouse
  • Nuclear Proteins
  • Nuclear Receptor Interacting Protein 1
  • beta Catenin