Advances and applications of single-cell sequencing technologies

Yong Wang; Nicholas E Navin

doi:10.1016/j.molcel.2015.05.005

Advances and applications of single-cell sequencing technologies

Mol Cell. 2015 May 21;58(4):598-609. doi: 10.1016/j.molcel.2015.05.005.

Authors

Yong Wang¹, Nicholas E Navin²

Affiliations

¹ Department of Genetics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.
² Department of Genetics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Bioinformatics and Computational Biology, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: nnavin@mdanderson.org.

Abstract

Single-cell sequencing (SCS) has emerged as a powerful new set of technologies for studying rare cells and delineating complex populations. Over the past 5 years, SCS methods for DNA and RNA have had a broad impact on many diverse fields of biology, including microbiology, neurobiology, development, tissue mosaicism, immunology, and cancer research. In this review, we will discuss SCS technologies and applications, as well as translational applications in the clinic.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Biomedical Research / methods*
Biomedical Research / trends
Forecasting
Genomics / methods*
High-Throughput Nucleotide Sequencing / methods*
Humans
Single-Cell Analysis / methods*

Abstract

Publication types

MeSH terms

Grants and funding