Abstract
A 63-year-old man with multiple HCC in his left liver lobe was enrolled as the first patient in a pilot study of boron neutron capture therapy (BNCT) involving the selective intra-arterial infusion of a (10)BSH-containing water-in-oil-in-water emulsion ((10)BSH-WOW). The size of the tumorous region remained stable during the 3 months after the BNCT. No adverse effects of the BNCT were observed. The present results show that (10)BSH-WOW can be used as novel intra-arterial boron carriers during BNCT for HCC.
Keywords:
Boron neutron capture therapy; Hepatocellular carcinoma; Intra-arterial injection; Water-in-oil-in-water emulsion.
Copyright © 2014 Elsevier Ltd. All rights reserved.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Borohydrides / administration & dosage*
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Borohydrides / chemistry
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Boron Neutron Capture Therapy / methods*
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Carcinoma, Hepatocellular / diagnosis
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Carcinoma, Hepatocellular / radiotherapy*
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Emulsions / administration & dosage
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Emulsions / chemistry
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Humans
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Injections, Intra-Arterial
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Liver Neoplasms / diagnosis
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Liver Neoplasms / radiotherapy*
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Male
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Middle Aged
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Neoplasm Recurrence, Local / diagnosis
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Neoplasm Recurrence, Local / radiotherapy*
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Oils / chemistry
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Pilot Projects
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Sulfhydryl Compounds / administration & dosage*
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Sulfhydryl Compounds / chemistry
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Treatment Outcome
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Water / chemistry
Substances
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Borohydrides
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Emulsions
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Oils
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Sulfhydryl Compounds
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Water
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mercaptoundecahydrododecaborate