Abstract
Since the last update on nerve conduits and allograft in 2000, investigations have established the efficacy of these alternatives to autograft in the repair of small sensory neural gaps. However, limited insights into the biology of the regenerating nerve continue to preclude intelligent conduit design. Ongoing discoveries in neuroscience and biomaterial engineering hold promise for the eventual development of allograft and conduits with potential of surpassing nerve autografts in clinical efficacy. In this review, we summarize the history, recent advances, and emerging developments in nerve conduits and allograft.
Keywords:
Allograft; Nerve conduit; Peripheral nerve injury; Peripheral nerve repair.
Published by Elsevier Inc.
Publication types
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Historical Article
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Review
MeSH terms
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Allografts
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Biocompatible Materials
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Cell-Free System / transplantation
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Chitosan
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Collagen Type I
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Fibrin
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Guided Tissue Regeneration / methods
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History, 19th Century
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History, 20th Century
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Humans
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Microsurgery / trends
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Nerve Regeneration
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Neurosurgical Procedures / methods*
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Neurosurgical Procedures / trends
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Peripheral Nerve Injuries / surgery*
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Peripheral Nerves / anatomy & histology
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Peripheral Nerves / physiopathology
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Peripheral Nerves / transplantation*
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Polyesters
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Polyglycolic Acid
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Prostheses and Implants*
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Tissue Engineering
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Tissue Scaffolds
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Transplantation, Autologous
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Vascular Grafting
Substances
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Biocompatible Materials
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Collagen Type I
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Polyesters
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Polyglycolic Acid
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lactide-caprolactone copolymer
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Fibrin
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Chitosan