Immunogenic tumor cell death induced by chemoradiotherapy: molecular mechanisms and a clinical translation

Cell Death Dis. 2013 Jun 20;4(6):e688. doi: 10.1038/cddis.2013.207.

Abstract

Chemoradiotherapy can induce immunogenic cell death, triggering danger signals such as high-mobility group box 1 protein, and resulting in T-cell immunity. This concept can potentially be harnessed for clinical therapy to enhance tumor-specific immunity. There is however limited information to translate this theory directly in a clinical setting. In this review, we will discuss and summarize molecular and cellular mechanisms underlying immunogenic tumor cell death induced by chemoradiotherapy, with emphasis on a clinical translation.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigens, Neoplasm / immunology
  • Calreticulin / metabolism
  • Chemoradiotherapy
  • Cytotoxicity, Immunologic
  • Dendritic Cells / immunology
  • Dendritic Cells / metabolism
  • HMGB1 Protein / metabolism
  • Humans
  • Neoplasms / immunology
  • Neoplasms / metabolism
  • Neoplasms / therapy*
  • T-Lymphocytes, Cytotoxic / immunology
  • T-Lymphocytes, Cytotoxic / metabolism
  • T-Lymphocytes, Cytotoxic / radiation effects
  • Toll-Like Receptor 4 / metabolism
  • Translational Research, Biomedical

Substances

  • Antigens, Neoplasm
  • Calreticulin
  • HMGB1 Protein
  • HMGB1 protein, human
  • TLR4 protein, human
  • Toll-Like Receptor 4