Abstract
Recurrence is not reliably predictable in localized clear cell renal cell carcinoma. Proteinmarkers could improve predictive accuracy. Tissue-microarrays from 132 patients with primary localized ccRCC were immunohistochemically analyzed for VHL, Ki67, p53, p21, survivin, and, for microvessel-density, UEA-1. Nuclear stainings of Ki67, p21, and survivin were significantly associated with disease-specific survival and increased predictive ability from 74% to 76%, 77%, and 78%, respectively in a multivariate model including T-stage and Fuhrman grade. A score-variable, combining Ki67-, p21-, and nS-staining identified a subset of patients with high risk of disease recurrence and increased predictive ability in the multivariate model to 84%.
MeSH terms
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Aged
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Biomarkers, Tumor / metabolism*
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Carcinoma, Renal Cell / blood supply
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Carcinoma, Renal Cell / metabolism*
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Carcinoma, Renal Cell / pathology*
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Cyclin-Dependent Kinase Inhibitor p21 / metabolism
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Female
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Humans
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Immunohistochemistry / methods
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Inhibitor of Apoptosis Proteins / metabolism
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Ki-67 Antigen / metabolism
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Kidney Neoplasms / blood supply
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Kidney Neoplasms / metabolism*
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Kidney Neoplasms / pathology*
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Male
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Microvessels / metabolism
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Microvessels / pathology
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Middle Aged
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Neoplasm Recurrence, Local / diagnosis
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Neoplasm Recurrence, Local / metabolism
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Neoplasm Recurrence, Local / pathology
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Prognosis
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Survivin
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Tumor Suppressor Protein p53 / metabolism
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Von Hippel-Lindau Tumor Suppressor Protein / metabolism
Substances
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BIRC5 protein, human
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Biomarkers, Tumor
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CDKN1A protein, human
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Cyclin-Dependent Kinase Inhibitor p21
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Inhibitor of Apoptosis Proteins
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Ki-67 Antigen
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Survivin
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Tumor Suppressor Protein p53
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Von Hippel-Lindau Tumor Suppressor Protein
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VHL protein, human