The search for effective therapy for sepsis: back to the drawing board?

JAMA. 2011 Dec 21;306(23):2614-5. doi: 10.1001/jama.2011.1853.
No abstract available

MeSH terms

  • Animals
  • Anti-Infective Agents / therapeutic use
  • Clinical Trials as Topic
  • Disaccharides / therapeutic use
  • Drug Discovery*
  • Humans
  • Immune Tolerance
  • Infections / complications
  • Models, Animal
  • Patient Selection
  • Protein C / therapeutic use
  • Recombinant Proteins / therapeutic use
  • Sepsis / drug therapy*
  • Sepsis / immunology*
  • Sepsis / mortality
  • Sepsis / physiopathology
  • Sugar Phosphates / therapeutic use
  • Toll-Like Receptor 4 / antagonists & inhibitors
  • Treatment Failure

Substances

  • Anti-Infective Agents
  • Disaccharides
  • Protein C
  • Recombinant Proteins
  • Sugar Phosphates
  • Toll-Like Receptor 4
  • eritoran
  • drotrecogin alfa activated