Abstract
Genetic studies and other experimental data have linked inflammatory bowel diseases with inflammasome activation. In this issue of Immunity, Zaki et al. (2010) and Dupaul-Chicoine et al. (2010) provide a detailed characterization of the regulatory task of the inflammasome in intestinal epithelial cells.
MeSH terms
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Animals
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Carrier Proteins / genetics
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Carrier Proteins / immunology
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Caspase 1 / deficiency
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Caspase 1 / immunology
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Caspase 1 / metabolism
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Caspase 12 / deficiency
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Caspase 12 / immunology
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Caspase 12 / metabolism
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Colitis / enzymology
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Colitis / genetics
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Colitis / immunology*
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Colitis / pathology
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Epithelial Cells / cytology
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Epithelial Cells / immunology
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Humans
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Interleukin-18 / biosynthesis
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Interleukin-18 / immunology*
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Mice
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NLR Family, Pyrin Domain-Containing 3 Protein
Substances
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Carrier Proteins
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Interleukin-18
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NLR Family, Pyrin Domain-Containing 3 Protein
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Nlrp3 protein, mouse
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Caspase 12
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Caspase 1