Interleukin-18 in intestinal inflammation: friend and foe?

Immunity. 2010 Mar 26;32(3):300-2. doi: 10.1016/j.immuni.2010.03.010.

Abstract

Genetic studies and other experimental data have linked inflammatory bowel diseases with inflammasome activation. In this issue of Immunity, Zaki et al. (2010) and Dupaul-Chicoine et al. (2010) provide a detailed characterization of the regulatory task of the inflammasome in intestinal epithelial cells.

Publication types

  • Comment

MeSH terms

  • Animals
  • Carrier Proteins / genetics
  • Carrier Proteins / immunology
  • Caspase 1 / deficiency
  • Caspase 1 / immunology
  • Caspase 1 / metabolism
  • Caspase 12 / deficiency
  • Caspase 12 / immunology
  • Caspase 12 / metabolism
  • Colitis / enzymology
  • Colitis / genetics
  • Colitis / immunology*
  • Colitis / pathology
  • Epithelial Cells / cytology
  • Epithelial Cells / immunology
  • Humans
  • Interleukin-18 / biosynthesis
  • Interleukin-18 / immunology*
  • Mice
  • NLR Family, Pyrin Domain-Containing 3 Protein

Substances

  • Carrier Proteins
  • Interleukin-18
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • Nlrp3 protein, mouse
  • Caspase 12
  • Caspase 1