The yin-yang of tumor-associated neutrophils

Alberto Mantovani

doi:10.1016/j.ccr.2009.08.014

The yin-yang of tumor-associated neutrophils

Cancer Cell. 2009 Sep 8;16(3):173-4. doi: 10.1016/j.ccr.2009.08.014.

Author

Alberto Mantovani¹

Affiliation

¹ Istituto Clinico Humantas IRCCS and Department of Translational Medicine, University of Milan, Milan, Italy. alberto.mantovani@humanitas.it

PMID: 19732714
DOI: 10.1016/j.ccr.2009.08.014

Abstract

Cancer-related inflammation is a key component of the tumor microenvironment. A report in this issue of Cancer Cell now indicates that tumor-associated neutrophils in lung cancer can polarize to either "N1" or "N2" phenotype that inhibits or promotes cancer development, respectively.

Publication types

Comment
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Carcinoma, Non-Small-Cell Lung / immunology*
Carcinoma, Non-Small-Cell Lung / pathology
Lung Neoplasms / immunology*
Lung Neoplasms / pathology
Mice
Neutrophils / immunology*
Neutrophils / pathology
Small Cell Lung Carcinoma / immunology*
Small Cell Lung Carcinoma / pathology
Yin-Yang*