Aggrecanase and aggrecan degradation in osteoarthritis: a review

J Int Med Res. 2008 Nov-Dec;36(6):1149-60. doi: 10.1177/147323000803600601.

Abstract

Aggrecanase-mediated aggrecan degradation is a significant event in early-stage osteoarthritis (OA). Aggrecanases belonging to the 'A Disintegrin And Metalloproteinase with ThromboSpondin motifs' (ADAMTS) family of proteinases play a significant role in aggrecan depletion in osteoarthritic cartilage. There has been considerable interest in the possible role of these aggrecanases, especially ADAMTS-4 and ADAMTS-5, as therapeutic targets in OA. This article discusses recent data regarding ADAMTS-4 and ADAMTS-5 in OA, with emphasis on the relationship between aggrecanase and aggrecan degradation as well as the role of aggrecanase in OA.

Publication types

  • Review

MeSH terms

  • ADAM Proteins / antagonists & inhibitors
  • ADAM Proteins / metabolism*
  • ADAMTS4 Protein
  • ADAMTS5 Protein
  • Aggrecans / metabolism*
  • Extracellular Matrix / enzymology
  • Humans
  • Osteoarthritis / enzymology*
  • Procollagen N-Endopeptidase / antagonists & inhibitors
  • Procollagen N-Endopeptidase / metabolism*
  • Tissue Inhibitor of Metalloproteinase-3 / metabolism
  • Tissue Inhibitor of Metalloproteinase-3 / pharmacology

Substances

  • ACAN protein, human
  • Aggrecans
  • TIMP3 protein, human
  • Tissue Inhibitor of Metalloproteinase-3
  • ADAM Proteins
  • ADAMTS5 Protein
  • ADAMTS5 protein, human
  • Procollagen N-Endopeptidase
  • ADAMTS4 Protein
  • ADAMTS4 protein, human