Abstract
CD40--which is expressed on endothelial cells and antigen-presenting cells, such as B cells, macrophages and dendritic cells--is a glycoprotein receptor for T cell-expressed CD40-ligand. CD40 signaling leads to production of both pro-inflammatory and anti-inflammatory mediators. Some of these mediators, such as vascular endothelial growth factor, help in angiogenesis, forming new capillaries. Although these capillaries can function as conduits for tumor-cell metastasis, these same vessels can also be a gateway for entry of activated anti-tumor effector cells that eliminate tumors. How such countercurrent processes can be turned in favor of anti-tumor immunity remains to be shown.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Angiopoietins / immunology
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Angiopoietins / metabolism
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Animals
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Antigen-Presenting Cells / immunology
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Antigen-Presenting Cells / metabolism*
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CD40 Antigens / immunology
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CD40 Antigens / metabolism*
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Chemokines / immunology
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Chemokines / metabolism
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Endothelial Cells / immunology*
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Endothelial Cells / metabolism
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Humans
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Neoplasm Metastasis
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Neoplasms / blood supply
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Neoplasms / immunology*
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Neoplasms / metabolism
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Neoplasms / pathology
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Neovascularization, Pathologic
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Signal Transduction
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Tumor Escape*
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Vascular Endothelial Growth Factor A / immunology
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Vascular Endothelial Growth Factor A / metabolism*
Substances
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Angiopoietins
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CD40 Antigens
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Chemokines
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Vascular Endothelial Growth Factor A