Genome regulation by polycomb and trithorax proteins

Bernd Schuettengruber; Daniel Chourrout; Michel Vervoort; Benjamin Leblanc; Giacomo Cavalli

doi:10.1016/j.cell.2007.02.009

Genome regulation by polycomb and trithorax proteins

Cell. 2007 Feb 23;128(4):735-45. doi: 10.1016/j.cell.2007.02.009.

Authors

Bernd Schuettengruber¹, Daniel Chourrout, Michel Vervoort, Benjamin Leblanc, Giacomo Cavalli

Affiliation

¹ Institute of Human Genetics, CNRS, 141, rue de la Cardonille, 34396 Montpellier Cedex 5, France.

PMID: 17320510
DOI: 10.1016/j.cell.2007.02.009

Abstract

Polycomb group (PcG) and trithorax group (trxG) proteins are critical regulators of numerous developmental genes. To silence or activate gene expression, respectively, PcG and trxG proteins bind to specific regions of DNA and direct the posttranslational modification of histones. Recent work suggests that PcG proteins regulate the nuclear organization of their target genes and that PcG-mediated gene silencing involves noncoding RNAs and the RNAi machinery.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Chromosomal Proteins, Non-Histone / genetics*
Chromosomal Proteins, Non-Histone / metabolism
Drosophila Proteins / genetics*
Drosophila Proteins / metabolism
Epigenesis, Genetic / genetics*
Evolution, Molecular
Gene Expression Regulation, Developmental / genetics*
Histones / genetics
Histones / metabolism
Humans
Polycomb-Group Proteins
RNA Interference / physiology*
RNA, Untranslated / genetics
RNA, Untranslated / metabolism
Repressor Proteins / genetics*
Repressor Proteins / metabolism

Substances

Chromosomal Proteins, Non-Histone
Drosophila Proteins
Histones
Polycomb-Group Proteins
RNA, Untranslated
Repressor Proteins
trx protein, Drosophila