Abstract
Interleukin (IL)-10 performs an irreplaceable role in negatively regulating inflammation, primarily through a mechanism that selectively blocks the expression of pro-inflammatory genes encoding cytokines, chemokines, cell-surface molecules and other molecules involved in the propagation of inflammation. Not surprisingly, IL-10 has attracted interest as a tool to regulate inflammatory diseases. The clinical use of IL-10 as an anti-inflammatory agent has, however, not met expectations. Nevertheless, the signaling pathway used by the IL-10 receptor to generate the anti-inflammatory response is only beginning to be understood and could be a way to regulate inflammation by pharmacological agents.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antineoplastic Agents / pharmacology
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Antineoplastic Agents / therapeutic use
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Dendritic Cells / metabolism
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Humans
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Inflammation / genetics
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Inflammation / metabolism*
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Interleukin-10 / metabolism*
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Macrophages / metabolism
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Neoplasms / drug therapy
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Neoplasms / metabolism
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Receptors, Interleukin-10 / metabolism
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STAT3 Transcription Factor / antagonists & inhibitors
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STAT3 Transcription Factor / metabolism*
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Signal Transduction* / drug effects
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T-Lymphocytes / metabolism
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Toxoplasma / metabolism
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Toxoplasma / pathogenicity
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Transcription, Genetic
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Vaccinia virus / metabolism
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Vaccinia virus / pathogenicity
Substances
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Antineoplastic Agents
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Receptors, Interleukin-10
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STAT3 Transcription Factor
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Interleukin-10